Carbidopa-Levodopa-Entacapone

Carbidopa-Levodopa-Entacapone helps manage advanced Parkinson’s disease symptoms. It boosts dopamine levels to reduce tremors, rigidity, and movement difficulty. Entacapone prolongs Levodopa’s effect, offering longer relief between doses. The combination supports smoother muscle function and better mobility. It’s recommended for long-term therapy under close medical care.

$1.33 – $1.69

	Carbidopa-Levodopa-Entacapone 50mg (12.5mg-50mg-200mg) $1.69 – $2.07	Select options This product has multiple variants. The options may be chosen on the product page
	Carbidopa-Levodopa-Entacapone 100mg (25mg-100mg-200mg) $1.33 – $1.63	Select options This product has multiple variants. The options may be chosen on the product page
	Carbidopa-Levodopa-Entacapone 150mg (37.5mg-150mg-200mg) $1.61 – $1.97	Select options This product has multiple variants. The options may be chosen on the product page

Category:

Anti Parkinson

Description

What is Carbidopa-Levodopa-Entacapone?

Carbidopa-Levodopa-Entacapone is a combination medicine used to manage symptoms of Parkinson’s disease more effectively than standard therapy alone. It helps control tremors, stiffness, slow movements, and muscle rigidity by improving dopamine levels in the brain. This treatment is commonly available in tablet form and is prescribed when patients experience “wearing-off” periods with regular Carbidopa-Levodopa.

Carbidopa-Levodopa-Entacapone Used For

This combination medicine is commonly prescribed for:

Parkinson’s disease
Parkinsonism related to dopamine imbalance
Patients who experience sudden return of symptoms between doses
Adults who need extended symptom control during the day

It helps smooth out fluctuations and provides more consistent relief.

Chemical Composition

Carbidopa-Levodopa-Entacapone tablets contain three active components:

Levodopa – converts into dopamine in the brain
Carbidopa – prevents levodopa from breaking down before it reaches the brain
Entacapone – boosts levodopa’s effectiveness by slowing its breakdown

This triple combination improves dopamine levels more steadily.

Carbidopa-Levodopa-Entacapone Mechanism

The medicine works on three levels:

Levodopa becomes dopamine once it reaches the brain.
Carbidopa ensures that levodopa is protected as it travels through the body.
Entacapone extends the effect of levodopa by blocking COMT, an enzyme that breaks it down.

This mechanism helps reduce motor symptoms and makes daily movement easier.

How It Helps Improve Symptom Control

Parkinson’s disease causes a loss of dopamine-producing cells, leading to movement problems. This combination therapy helps maintain stable dopamine levels throughout the day. It reduces:

Sudden “off” episodes
Muscle tightness
Tremors
Walking and balance difficulties
Slow or stiff movements

Patients often experience smoother control with fewer fluctuations.

What Are Other Benefits?

Helps manage symptoms when regular Carbidopa-Levodopa becomes less effective
Reduces the need for frequent dosing
Provides more consistent symptom relief
Helpful for patients with significant wearing-off periods
Available in multiple strengths to match treatment needs

Dosages

Available Strengths or Dosage

Carbidopa-Levodopa-Entacapone tablets come in various strengths, often including:

12.5 mg / 50 mg / 200 mg
25 mg / 100 mg / 200 mg
37.5 mg / 150 mg / 200 mg
50 mg / 200 mg / 200 mg

Each tablet contains a fixed amount of entacapone (200 mg) along with different carbidopa and levodopa levels.

Your doctor selects the strength based on symptom control and previous levodopa dose.

How and When to Take It

Take the tablet exactly as prescribed
Swallow whole with water; do not crush or split
Take doses at evenly spaced times throughout the day
You may take it with or without food
Protein-heavy meals may affect absorption, so follow your doctor’s advice
Maintain a consistent schedule for best results

If you forget a dose, take it when you remember, unless the next dose is near.

Overdose Caution

Signs of overdose may include:

Severe confusion
Fast heartbeat
Uncontrolled movements
Vomiting
Difficulty breathing
Extreme sleepiness

Seek emergency medical help if overdose is suspected.

Who Can Use/Take Carbidopa-Levodopa-Entacapone?

This medicine is designed for adults with Parkinson’s disease who need better control of symptoms or experience wearing-off episodes. It is not recommended for children.

Use with caution if you have:

Heart disease
Severe liver issues
History of mental health disorders
Glaucoma
Low blood pressure
Digestive tract problems

Pregnant or breastfeeding women should use it only if a doctor advises it.

Carbidopa-Levodopa-Entacapone: Side Effects & Precautions

What Are the Side Effects?

Common side effects may include:

Nausea
Dizziness
Sleepiness
Diarrhea
Fatigue
Headache
Dry mouth
Muscle movements (dyskinesia)

Less common but serious side effects include:

Hallucinations
Sudden sleep episodes
Irregular heartbeat
Confusion
Severe diarrhea
Mood or behavior changes

Report serious symptoms immediately.

Precautions to Avoid Side Effects

Follow your dosing schedule exactly
Do not stop the medicine suddenly
Avoid driving if you feel sleepy or dizzy
Tell your doctor about all other medicines you take
Reduce alcohol use to avoid side effects
Monitor blood pressure regularly
Attend scheduled doctor visits for dose adjustments

These steps help ensure safe and stable treatment.

Always consult your neurologist before starting Carbidopa-Levodopa-Entacapone. If prescribed, you can order Carbidopa-Levodopa-Entacapone tablets safely online from trusted pharmacy sources to maintain consistent treatment and symptom control.