Carbidopa-Levodopa-Entacapone 150mg Uses

Carbidopa-Levodopa-Entacapone 150mg (37.5mg-150mg-200mg) is prescribed for:

  • Parkinson’s Disease: Effectively manages motor symptoms like rigidity, tremors, and bradykinesia (slowness of movement).
  • Reduction of Motor Fluctuations: Reduces “off” periods when Parkinson’s symptoms return due to decreased dopamine levels.

This formulation provides enhanced symptom control, particularly for individuals with fluctuating response to Levodopa.

How Does Carbidopa-Levodopa-Entacapone 150mg Work?

This combination medication contains three active ingredients:

  • Levodopa: Converts into dopamine in the brain, replenishing low levels and improving motor function.
  • Carbidopa: Prevents the breakdown of Levodopa in the bloodstream, ensuring more of the medication reaches the brain and reducing side effects like nausea.
  • Entacapone: Inhibits the COMT enzyme, which breaks down Levodopa, prolonging its effects and reducing motor fluctuations.

Together, these components enhance and stabilize dopamine levels, offering prolonged symptom relief and better overall management of Parkinson’s disease.

How to Use Carbidopa-Levodopa-Entacapone 150mg

  1. Dosage: Take Carbidopa-Levodopa-Entacapone 150mg as prescribed by your doctor. The dose will depend on your condition and response to treatment.
  2. Administration: Swallow the tablet whole with water. Do not crush, chew, or split the tablet.
  3. Timing: Take the medication at regular intervals as directed by your doctor to maintain consistent drug levels.
  4. Food: You may take it with or without food, but avoid high-protein meals near dosing as they may interfere with Levodopa’s absorption.

Side Effects

Common side effects of Carbidopa-Levodopa-Entacapone 150mg include:

  • Nausea or vomiting
  • Diarrhea
  • Drowsiness or dizziness
  • Dry mouth
  • Involuntary movements (dyskinesia)

In rare cases, severe side effects such as hallucinations, confusion, mood changes, or severe diarrhea may occur. Contact your healthcare provider immediately if you experience these symptoms.

Drug Interactions

Carbidopa-Levodopa-Entacapone 150mg may interact with other medications, potentially altering its effectiveness or increasing side effects. Inform your doctor if you are taking:

  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • Antipsychotic medications
  • Iron supplements (may reduce absorption)
  • Blood pressure-lowering drugs

Food Interactions

Avoid consuming high-protein meals close to the time of taking Carbidopa-Levodopa-Entacapone 150mg, as protein can interfere with Levodopa’s absorption. Spacing protein intake evenly throughout the day helps maintain medication effectiveness.

Contraindications

Carbidopa-Levodopa-Entacapone 150mg is contraindicated in individuals who:

  • Are allergic to Carbidopa, Levodopa, Entacapone, or any other ingredients in the medication
  • Have narrow-angle glaucoma
  • Have severe liver impairment
  • Are taking non-selective MAO inhibitors

Precautions and Warnings

  • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding, as this medication may affect the baby.
  • Driving and Machinery: Avoid activities requiring alertness, such as driving, until you understand how the medication affects you, as it may cause dizziness or drowsiness.
  • Monitoring: Regular check-ups and blood tests are necessary to monitor your condition, liver function, and any side effects.
  • Sudden Discontinuation: Do not stop taking the medication abruptly, as it may worsen symptoms or cause withdrawal effects.

Storage

Store Carbidopa-Levodopa-Entacapone 150mg at room temperature, away from moisture, heat, and direct sunlight. Keep it out of reach of children and pets. Dispose of unused or expired medication responsibly.

Quantity 100, 150, 200, 50
Manufacturer Sun Pharma
Indian Brand Syncapone 150
US Brand Name Carbidopa-Levodopa-Entacapone, Stalevo
Generic Name Carbidopa-Levodopa-Entacapone
Dosage 150mg 37.5mg-150mg-200mg
Drug Type Tablets
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