Carbidopa-Levodopa-Entacapone 50mg Uses

Carbidopa-Levodopa-Entacapone 50mg (12.5mg-50mg-200mg) is prescribed for:

  • Parkinson’s Disease: Helps manage motor symptoms, including rigidity, tremors, and bradykinesia (slowness of movement).
  • Fluctuations in Symptom Control: Reduces “off” periods when symptoms return due to low dopamine levels.

This formulation is particularly effective for individuals requiring more stable and sustained symptom relief.

How Does Carbidopa-Levodopa-Entacapone 50mg Work?

This combination medication includes three active ingredients:

  • Levodopa: Converts into dopamine in the brain, replenishing low levels to improve motor function and reduce symptoms.
  • Carbidopa: Prevents Levodopa from breaking down in the bloodstream, ensuring it reaches the brain and reducing side effects such as nausea.
  • Entacapone: Inhibits the COMT enzyme, which breaks down Levodopa, prolonging its effects and enhancing symptom control.

Together, these ingredients stabilize dopamine levels, minimizing motor fluctuations and providing extended relief.

How to Use Carbidopa-Levodopa-Entacapone 50mg

  1. Dosage: Take Carbidopa-Levodopa-Entacapone 50mg as prescribed by your healthcare provider. The dosage depends on your condition and response to treatment.
  2. Administration: Swallow the tablet whole with water; do not crush, chew, or split it.
  3. Timing: Take the medication at regular intervals as directed to maintain consistent drug levels.
  4. Food: You may take it with or without food, but avoid high-protein meals near dosing as they can interfere with Levodopa’s absorption.

Side Effects

Common side effects of Carbidopa-Levodopa-Entacapone 50mg include:

  • Nausea or vomiting
  • Drowsiness or dizziness
  • Diarrhea
  • Dry mouth
  • Involuntary movements (dyskinesia)

Severe side effects, such as hallucinations, confusion, mood changes, or severe diarrhea, should be reported to your doctor immediately.

Drug Interactions

Carbidopa-Levodopa-Entacapone 50mg may interact with other medications, potentially altering its effectiveness or increasing the risk of side effects. Inform your healthcare provider if you are taking:

  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • Antipsychotic medications
  • Iron supplements (may reduce absorption)
  • Blood pressure-lowering drugs

Food Interactions

Avoid consuming high-protein meals close to the time of taking Carbidopa-Levodopa-Entacapone 50mg, as protein can interfere with the absorption of Levodopa. Spacing protein intake evenly throughout the day helps maintain medication effectiveness.

Contraindications

Carbidopa-Levodopa-Entacapone 50mg is contraindicated in individuals who:

  • Are allergic to Carbidopa, Levodopa, Entacapone, or any other ingredients in the medication
  • Have narrow-angle glaucoma
  • Have severe liver impairment
  • Are taking non-selective MAO inhibitors

Precautions and Warnings

  • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding, as this medication may affect the baby.
  • Driving and Machinery: Avoid activities requiring alertness, such as driving, until you understand how the medication affects you, as it may cause dizziness or drowsiness.
  • Monitoring: Regular check-ups and blood tests are necessary to monitor your condition, liver function, and side effects.
  • Sudden Discontinuation: Do not stop taking the medication abruptly, as it may worsen symptoms or cause withdrawal effects.

Storage

Store Carbidopa-Levodopa-Entacapone 50mg at room temperature, away from heat, moisture, and direct sunlight. Keep the medication out of reach of children and pets. Dispose of unused or expired medication responsibly.

Quantity 100, 150, 200, 50
Manufacturer Sun Pharma
Indian Brand Syncapone 50
US Brand Name Carbidopa-Levodopa-Entacapone, Stalevo
Generic Name Carbidopa-Levodopa-Entacapone
Dosage 50mg 12.5mg-50mg-200mg
Drug Type Tablets
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