Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg Uses

This medication is prescribed to:

  • Improve blood sugar control in adults with type 2 diabetes mellitus.
  • Offer a dual mechanism of action when single-agent therapy is insufficient.
  • Help reduce the risk of diabetes-related complications through effective blood sugar management.

How Does Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg Work

  • Sitagliptin: A DPP-4 inhibitor that enhances incretin hormone activity, stimulating insulin secretion and reducing glucose production by the liver after meals.
  • Metformin: Lowers glucose production in the liver and increases insulin sensitivity, allowing better glucose uptake by cells.

The combination targets multiple pathways to provide a robust and sustained reduction in blood sugar levels.

How to Use Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg

  • Take this medication exactly as prescribed by your healthcare provider, typically twice daily with meals.
  • Swallow the tablet whole with water to minimize gastrointestinal side effects.
  • Do not crush, split, or chew the tablet.
  • Follow your doctor’s recommendations for a healthy diet and regular exercise regimen to maximize effectiveness.

Side Effects

Common side effects may include:

  • Nausea, diarrhea, or abdominal discomfort
  • Headache or dizziness
  • Upper respiratory symptoms, such as a sore throat or nasal congestion

Rare but serious side effects include:

  • Lactic acidosis (a rare condition marked by muscle pain, breathing difficulties, or extreme fatigue).
  • Pancreatitis, with symptoms such as severe abdominal pain or persistent vomiting.
  • Severe allergic reactions, such as rash, swelling, or difficulty breathing.
  • Low blood sugar (hypoglycemia), especially when used with insulin or sulfonylureas.

Drug Interactions

Sitagliptin Phosphate-Metformin Hydrochloride may interact with:

  • Alcohol, increasing the risk of lactic acidosis.
  • Other antidiabetic medications, which may heighten the risk of hypoglycemia.
  • Kidney-impacting medications, as both Sitagliptin and Metformin are excreted renally.
  • Digoxin, requiring dose adjustments or monitoring.

Food Interactions

  • Take the tablet with meals to reduce gastrointestinal discomfort.
  • Avoid excessive alcohol consumption, as it may increase the risk of lactic acidosis.

Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg Contraindications

This medication is not suitable for:

  • Individuals allergic to Sitagliptin, Metformin, or any other components.
  • Patients with type 1 diabetes or diabetic ketoacidosis.
  • Individuals with severe kidney impairment or metabolic acidosis.
  • Pregnant or breastfeeding women unless specifically recommended by a healthcare provider.

Precautions and Warnings

  • Inform your doctor if you have a history of kidney or liver problems, as the medication may require dosage adjustments.
  • Monitor for symptoms of lactic acidosis, such as unusual tiredness, muscle pain, or shortness of breath.
  • Regular blood tests are essential to evaluate kidney function and blood sugar control.
  • Avoid using this medication in elderly patients without close monitoring, as they may be more prone to side effects.

Storage

  • Store Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg tablets at room temperature, away from moisture, heat, and light.
  • Keep the medication in its original packaging and out of reach of children and pets.
  • Dispose of unused or expired tablets responsibly, following local disposal guidelines.

Safety Information

  • Use this combination medication only as directed by your healthcare provider.
  • Do not adjust your dosage or discontinue use without consulting your doctor.
  • Report any unusual symptoms, such as persistent gastrointestinal distress, severe allergic reactions, or signs of lactic acidosis, to your healthcare provider immediately.
Quantity 120, 30, 60, 90
Manufacturer Sun Pharma
Indian Brand Sitared-M 50/500
US Brand Name Sitagliptin Phosphate-Metformin Hydrochloride
Generic Name Sitagliptin Phosphate-Metformin Hydrochloride
Dosage 50mg-500mg
Drug Type Tablets
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  • We only collect information with the full knowledge and consent of our customers. Even while using or disclosing the information, the customers’ consent is required unless otherwise specified by the law.
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Collection of personal information

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  • Prescription information

It is fully left to the discretion of our customers whether or not they chose to provide us with this information and how much information they provide us with. However, we make recommendations based on the information that they provide and it becomes difficult for us to suggest alternatives if we have not been given adequate information. We may even request additional information in case we are not able to carry out the request based on the information provided. We also maintain a file on our customers on their personal information that our customers can update from time to time.

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Customers’ consent is always taken before making use of their personal information. We only use their personal information for the purposes that we disclose to them.

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Customers’ personal information is shared with an outside source only under the following circumstances:

  • To fulfill a prescription: The information maybe shared with our affiliate or licensed pharmacy in order to procure the necessary prescription
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Customers can access and modify their information in case they wish to make any changes or corrections in case of a clerical error on our part. Once the customer informs us about the incorrect or old information in their file, we carry out the necessary changes. We also make these changes known to any other parties who we may have passed the incorrect information onto.

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Updating the policy

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