Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg

Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg Uses

This medication is prescribed to:

• Improve blood sugar control in adults with type 2 diabetes mellitus.
• Offer a dual mechanism of action when single-agent therapy is insufficient.
• Help reduce the risk of diabetes-related complications through effective blood sugar management.

How Does Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg Work

• Sitagliptin: A DPP-4 inhibitor that enhances incretin hormone activity, stimulating insulin secretion and reducing glucose production by the liver after meals.
• Metformin: Lowers glucose production in the liver and increases insulin sensitivity, allowing better glucose uptake by cells.

The combination targets multiple pathways to provide a robust and sustained reduction in blood sugar levels.

How to Use Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg

• Take this medication exactly as prescribed by your healthcare provider, typically twice daily with meals.
• Swallow the tablet whole with water to minimize gastrointestinal side effects.
• Do not crush, split, or chew the tablet.
• Follow your doctor’s recommendations for a healthy diet and regular exercise regimen to maximize effectiveness.

Side Effects

Common side effects may include:

• Nausea, diarrhea, or abdominal discomfort
• Headache or dizziness
• Upper respiratory symptoms, such as a sore throat or nasal congestion

Rare but serious side effects include:

• Lactic acidosis (a rare condition marked by muscle pain, breathing difficulties, or extreme fatigue).
• Pancreatitis, with symptoms such as severe abdominal pain or persistent vomiting.
• Severe allergic reactions, such as rash, swelling, or difficulty breathing.
• Low blood sugar (hypoglycemia), especially when used with insulin or sulfonylureas.

Drug Interactions

Sitagliptin Phosphate-Metformin Hydrochloride may interact with:

• Alcohol, increasing the risk of lactic acidosis.
• Other antidiabetic medications, which may heighten the risk of hypoglycemia.
• Kidney-impacting medications, as both Sitagliptin and Metformin are excreted renally.
• Digoxin, requiring dose adjustments or monitoring.

Food Interactions

• Take the tablet with meals to reduce gastrointestinal discomfort.
• Avoid excessive alcohol consumption, as it may increase the risk of lactic acidosis.

Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg Contraindications

This medication is not suitable for:

• Individuals allergic to Sitagliptin, Metformin, or any other components.
• Patients with type 1 diabetes or diabetic ketoacidosis.
• Individuals with severe kidney impairment or metabolic acidosis.
• Pregnant or breastfeeding women unless specifically recommended by a healthcare provider.

Precautions and Warnings

• Inform your doctor if you have a history of kidney or liver problems, as the medication may require dosage adjustments.
• Monitor for symptoms of lactic acidosis, such as unusual tiredness, muscle pain, or shortness of breath.
• Regular blood tests are essential to evaluate kidney function and blood sugar control.
• Avoid using this medication in elderly patients without close monitoring, as they may be more prone to side effects.

Storage

• Store Sitagliptin Phosphate-Metformin Hydrochloride 50mg-500mg tablets at room temperature, away from moisture, heat, and light.
• Keep the medication in its original packaging and out of reach of children and pets.
• Dispose of unused or expired tablets responsibly, following local disposal guidelines.

Safety Information

• Use this combination medication only as directed by your healthcare provider.
• Do not adjust your dosage or discontinue use without consulting your doctor.
• Report any unusual symptoms, such as persistent gastrointestinal distress, severe allergic reactions, or signs of lactic acidosis, to your healthcare provider immediately.