Sitagliptin Phosphate-Metformin Hydrochloride 50mg-1000mg

Sitagliptin Phosphate-Metformin Hydrochloride 50mg-1000mg Uses

This combination medication is prescribed to:

• Improve blood sugar control in adults with type 2 diabetes mellitus.
• Provide enhanced benefits when single-agent therapy is insufficient.
• Reduce the risk of diabetes-related complications by maintaining stable blood sugar levels.

How Does Sitagliptin Phosphate-Metformin Hydrochloride 50mg-1000mg Work

• Sitagliptin: A DPP-4 inhibitor that preserves incretin hormones, stimulating insulin release and suppressing glucose production in response to meals.
• Metformin: Reduces glucose production in the liver and enhances the body’s ability to utilize insulin effectively.

This combination targets multiple pathways to regulate blood sugar and improve overall glycemic control.

How to Use Sitagliptin Phosphate-Metformin Hydrochloride 50mg-1000mg

• Take this medication exactly as prescribed by your healthcare provider, usually once or twice daily with meals.
• Swallow the tablet whole with water to avoid gastrointestinal side effects.
• Do not split, crush, or chew the tablet.
• Continue following a balanced diet and regular exercise routine as part of your diabetes management plan.

Side Effects

Common side effects may include:

• Nausea, diarrhea, or upset stomach
• Headache or dizziness
• Upper respiratory infections, such as a sore throat or runny nose

Rare but serious side effects include:

• Lactic acidosis (a rare but serious buildup of lactic acid), with symptoms such as muscle pain, difficulty breathing, or fatigue.
• Pancreatitis, with symptoms like severe abdominal pain or vomiting.
• Severe allergic reactions, such as rash, swelling, or difficulty breathing.
• Low blood sugar (hypoglycemia), especially when combined with insulin or sulfonylureas.

Drug Interactions

This combination medication may interact with:

• Alcohol, increasing the risk of lactic acidosis.
• Other antidiabetic medications, heightening the risk of hypoglycemia.
• Medications affecting kidney function, as both components are excreted renally.
• Digoxin, requiring monitoring if taken concurrently.

Food Interactions

• Take the tablet with food to reduce gastrointestinal side effects.
• Avoid excessive alcohol consumption, as it may increase the risk of lactic acidosis.

Sitagliptin Phosphate-Metformin Hydrochloride 50mg-1000mg Contraindications

This medication is not suitable for:

• Individuals allergic to Sitagliptin, Metformin, or any of the components.
• Patients with type 1 diabetes or diabetic ketoacidosis.
• Individuals with severe kidney impairment or metabolic acidosis.
• Pregnant or breastfeeding women unless specifically advised by a healthcare provider.

Precautions and Warnings

• Inform your doctor if you have a history of kidney, liver, or heart disease.
• Monitor for symptoms of lactic acidosis, such as unusual tiredness, weakness, or rapid breathing.
• Use with caution in elderly patients, who may be more prone to side effects.
• Regular blood tests are required to monitor kidney function and blood sugar levels.

Storage

• Store Sitagliptin Phosphate-Metformin Hydrochloride 50mg-1000mg tablets at room temperature, away from heat, moisture, and direct light.
• Keep the medication in its original packaging and out of reach of children and pets.
• Dispose of unused or expired tablets responsibly, following local disposal guidelines.

Safety Information

• Use this combination medication only as directed by your healthcare provider.
• Do not adjust the dosage or discontinue use without consulting your doctor.
• Report any unusual symptoms, such as severe gastrointestinal distress, signs of lactic acidosis, or allergic reactions, to your healthcare provider immediately.