Pirfenidone

What is Pirfenidone?

Pirfenidone is a prescription antifibrotic medicine used to slow the progression of idiopathic pulmonary fibrosis (IPF). This chronic lung condition causes scarring in the lungs, making breathing harder over time. The medicine works by reducing inflammation and slowing down the buildup of scar tissue. Many patients use Pirfenidone long-term to maintain lung function, support better breathing, and reduce the speed at which the disease progresses.

Pirfenidone Used For

Pirfenidone is mainly prescribed to:

• Slow lung tissue scarring

• Improve long-term lung function in IPF

• Reduce inflammation in the lungs

• Support more stable breathing patterns

• Manage symptoms such as shortness of breath or persistent cough

This medicine is not a cure but helps delay worsening of the condition.

Chemical Composition

Pirfenidone tablets contain:

• Pirfenidone (active antifibrotic agent)

• Stabilizers

• Tablet binders

• Coating agents

The formulation ensures controlled absorption and steady levels in the bloodstream for consistent lung support.

Pirfenidone Mechanism

This medicine works by reducing the production of inflammatory chemicals that cause lung scarring. It also slows fibroblast activity—the process responsible for forming scar tissue. By targeting inflammation and fibrosis at the same time, Pirfenidone helps maintain healthier lung tissue and slows disease progression.

How It Helps Manage Lung Fibrosis

Idiopathic pulmonary fibrosis causes the lungs to stiffen. Pirfenidone helps by slowing the stiffening process. Patients may experience:

• Less rapid decline in breathing capacity

• Greater comfort during physical activity

• Fewer flare-ups

• Improved daily energy levels

Over time, consistent treatment may help patients maintain independence and quality of life.

What Are the Other Benefits?

Some added benefits may include:

• Reduced coughing episodes

• Slower reduction in oxygen levels

• Better exercise tolerance

• Lower risk of sudden progression events

• Improved ability to complete daily activities

Regular medical monitoring enhances these benefits and ensures proper dosing.

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Dosages

Your dose depends on your doctor’s treatment plan and how well your body adjusts during the first few weeks. Dosage is usually increased slowly to reduce side effects.

Available Strengths or Dosage

Pirfenidone is available in:

• 267 mg tablets

• 801 mg tablets

These strengths allow a flexible dosing schedule, especially during the initial dose-titration phase.

How and When to Take It

To use Pirfenidone safely:

• Take tablets with food to reduce stomach upset.

• Do not crush or break the tablets.

• Follow the gradual dose increase recommended by your doctor.

• Take doses at the same time daily for best results.

• Avoid sunlight and UV exposure, as this medicine may increase sensitivity.

If you miss a dose, take it as soon as you remember unless it’s near the next scheduled dose.

Overdose Caution

Too much Pirfenidone may cause:

• Severe nausea

• Dizziness

• Stomach pain

• Skin reactions

• Breathing difficulty

If an overdose occurs, seek emergency medical support immediately.

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Who Can Use/Take Pirfenidone?

Pirfenidone may be recommended for:

• Adults diagnosed with idiopathic pulmonary fibrosis

• Patients needing long-term antifibrotic therapy

• Individuals with progressive lung scarring

It may not be suitable for:

• Children and adolescents

• People with severe liver or kidney impairment

• Individuals allergic to antifibrotic agents

• Those who consume high amounts of alcohol

• Pregnant or breastfeeding individuals unless doctor-approved

Your healthcare provider may run blood tests to ensure your organs can handle long-term use.

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Side Effects & Precautions

What Are the Side Effects?

Common side effects include:

• Loss of appetite

• Nausea

• Stomach upset

• Tiredness

• Headache

• Skin sensitivity to sunlight

• Weight loss

Less common but serious side effects may involve:

• Liver function changes

• Severe rash

• Breathing difficulty

Medical follow-up helps catch rare issues early.

What Are the Precautions to Avoid Side Effects?

To stay safe while using this medicine:

• Always take it with food.

• Avoid direct sunlight; use sunscreen and protective clothing.

• Limit alcohol intake to protect liver function.

• Stay hydrated to ease stomach-related symptoms.

• Do not adjust dose without your doctor’s approval.

• Complete regular liver tests as advised.

Report unusual symptoms such as yellowing of skin, dark urine, or unexplained fatigue.

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Always consult your doctor before starting this treatment. If prescribed, you can order Pirfenidone tablets online from trusted pharmacy sources and maintain timely refills to support long-term lung health.