What is Nintedanib 150mg Used For?

Nintedanib 150mg is a prescription medication used to treat:

  1. Idiopathic Pulmonary Fibrosis (IPF) – Slows lung scarring and helps maintain lung function.
  2. Chronic Fibrosing Interstitial Lung Diseases (ILDs) – Prevents excessive lung fibrosis and disease progression.
  3. Non-Small Cell Lung Cancer (NSCLC) – Used in combination with chemotherapy to inhibit cancer cell growth.

It works by blocking tyrosine kinases, which contribute to lung tissue scarring and cancer cell spread.

How to Use Nintedanib 150 mg

  • Take one capsule (150mg) twice daily (approximately 12 hours apart).
  • Always take with food to reduce stomach-related side effects.
  • Swallow the capsule whole with a full glass of water.
  • Do not crush, chew, or break the capsule.
Missed Dose:
  • Skip the missed dose if it’s almost time for the next one.
  • Do not double the dose to make up for a missed one.
Overdose Warning:
  • Overdosing can cause severe diarrhea, vomiting, and liver damage.
  • Seek immediate medical help if an overdose occurs.

Side Effects of Nintedanib

Like all medications, Nintedanib may cause side effects.

Common Side Effects:
  • Diarrhea (most frequent)
  • Nausea and vomiting
  • Loss of appetite
  • Weight loss
  • Liver enzyme elevation
Serious Side Effects (Seek Medical Attention):
  • Severe liver problems – Yellowing of the skin/eyes (jaundice).
  • Uncontrolled bleeding – Nosebleeds, easy bruising, or blood in urine/stool.
  • Gastrointestinal perforation – Severe stomach pain, fever, bloating.
How to Manage Side Effects:
  • Stay hydrated to prevent dehydration from diarrhea.
  • Use anti-nausea medications if needed.
  • Get regular liver function tests to monitor any issues.

Drug Interactions

Certain medications can increase side effects or reduce Nintedanib’s effectiveness.

Avoid Taking With:
  • Blood thinners (Warfarin, Aspirin) – Increases bleeding risk.
  • Strong CYP3A4 inhibitors (Ketoconazole, Ritonavir) – May raise drug levels in the body.
  • Rifampin (Antibiotic) – Can lower Nintedanib effectiveness.
What to Do:
  • Inform your doctor about all prescription and non-prescription medications.
  • Avoid herbal supplements that can affect liver function.

Warnings

Before taking Nintedanib 150mg, be aware of these safety concerns.

Who Should Avoid It?
  • Pregnant or breastfeeding women – Can harm an unborn baby.
  • Patients with severe liver disease – May worsen liver function.
  • People with bleeding disorders – Can increase bleeding risks.
Important Precautions:
  • Regular liver function tests are necessary.
  • Use reliable birth control while on this medication.
  • Monitor for severe stomach pain, which could indicate GI perforation.

Storage Instructions

  • Store at room temperature (15°C–30°C or 59°F–86°F).
  • Keep away from moisture and direct sunlight.
  • Store in its original packaging to protect from humidity.
  • Keep out of reach of children and pets.
Quantity 120, 30, 60, 90
Manufacturer Cipla Limited
Indian Brand Nintib 150mg
US Brand Name Ofev
Generic Name Nintedanib
Dosage 150mg
Drug Type Capsules

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