Uses of Nintedanib 100mg

  • Idiopathic Pulmonary Fibrosis (IPF): Slows the progression of lung scarring and helps improve quality of life.
  • Chronic Progressive Fibrosing ILDs: Reduces the worsening of symptoms in patients with certain fibrosing lung diseases.
  • Systemic Sclerosis-associated ILD (SSc-ILD): Helps manage lung involvement in systemic sclerosis by reducing disease progression.

How Does Nintedanib 100mg Work?

Nintedanib inhibits tyrosine kinases involved in the signaling pathways that promote fibrosis and scarring of lung tissues. By blocking these pathways, it reduces fibroblast activity and slows the progression of fibrotic processes in the lungs, helping to preserve lung function.

How to Use Nintedanib 100mg

  • Dosage: Take Nintedanib 100mg as directed by your healthcare provider, typically twice daily, 12 hours apart.
  • Administration: Swallow the capsule whole with water. Do not crush, chew, or break the capsule.
  • With Food: Take the medication with food to minimize gastrointestinal side effects.
  • Missed Dose: If you miss a dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed one.

Side Effects

Common side effects of Nintedanib 100mg include diarrhea, nausea, vomiting, abdominal pain, and decreased appetite.
Rare but serious side effects include elevated liver enzymes, severe diarrhea or dehydration, bleeding events (e.g., nosebleeds, gastrointestinal bleeding), and symptoms of severe liver damage such as yellowing of the skin or eyes.
Seek immediate medical attention if you experience severe or persistent side effects.

Drug Interactions

Nintedanib 100mg may interact with:

  • Anticoagulants or blood thinners (e.g., Warfarin, Heparin), increasing the risk of bleeding.
  • CYP3A4 inhibitors (e.g., Ketoconazole, Erythromycin), which may increase Nintedanib levels in the blood.
  • CYP3A4 inducers (e.g., Rifampin, Carbamazepine), which may reduce the effectiveness of Nintedanib.
  • NSAIDs and Aspirin, which may increase the risk of gastrointestinal side effects.
    Always inform your healthcare provider about all medications, supplements, and herbal products you are using.

Food Interactions

Take Nintedanib with food to improve tolerability and reduce gastrointestinal discomfort. Avoid excessive alcohol consumption, as it may increase the risk of liver-related side effects.

Contraindications

Nintedanib 100mg is contraindicated in individuals with known hypersensitivity to Nintedanib or any of its ingredients, severe liver impairment (Child-Pugh Class C), or active bleeding disorders. Your healthcare provider will evaluate your medical history to ensure this medication is safe for you.

Precautions and Warnings

  • Liver Function: Regular monitoring of liver enzymes is recommended during treatment to detect any early signs of liver damage.
  • Bleeding Risk: Use with caution in individuals with a history of bleeding disorders or those taking anticoagulants.
  • Gastrointestinal Health: Diarrhea is a common side effect; ensure adequate hydration and notify your doctor if symptoms are severe.
  • Pregnancy and Breastfeeding: Avoid use during pregnancy, as Nintedanib may harm the fetus. Use effective contraception during treatment and for at least 3 months after discontinuing. Consult your healthcare provider if you are breastfeeding.
  • Wound Healing: Notify your doctor before any planned surgeries, as Nintedanib may affect wound healing.

Safety Information

Seek immediate medical attention if you experience symptoms of severe liver damage, such as jaundice, dark urine, or persistent abdominal pain, unusual bleeding or bruising, or severe gastrointestinal symptoms like uncontrollable diarrhea or vomiting. Contact a healthcare provider immediately if overdose symptoms occur.

Storage

  • Store Nintedanib 100mg capsules at room temperature, between 20–25°C (68–77°F).
  • Keep the medication in a dry place, away from direct sunlight and excessive moisture.
  • Ensure the medication is out of reach of children and pets.
  • Dispose of unused or expired capsules responsibly, following local waste disposal guidelines.
Quantity 120, 180, 240, 60
Manufacturer Sun Pharma
Indian Brand Nintena 100mg 10's
US Brand Name Ofev
Generic Name Nintedanib
Dosage 100mg
Drug Type Capsules
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