Amlodipine-Lisinopril

What is Amlodipine-Lisinopril?

Amlodipine-Lisinopril is a combination medicine used to treat high blood pressure (hypertension) and certain types of heart disease. It contains two active ingredients — Amlodipine, a calcium channel blocker, and Lisinopril, an ACE inhibitor. Together, they help relax and widen blood vessels, making it easier for the heart to pump blood efficiently and reducing strain on the cardiovascular system.

Amlodipine-Lisinopril Used For

Amlodipine-Lisinopril tablets are primarily used to:

• Lower high blood pressure and reduce the risk of stroke or heart attack

• Manage chronic heart failure and coronary artery disease

• Improve blood flow in patients with angina or heart muscle weakness

By combining these two medicines, it offers more effective blood pressure control for patients who don’t achieve target levels with single-drug therapy.

Chemical Composition

Each Amlodipine-Lisinopril tablet typically contains Amlodipine Besylate (2.5 mg, 5 mg, or 10 mg) and Lisinopril (10 mg, 20 mg, or 40 mg). The inactive ingredients vary by manufacturer but may include cellulose, magnesium stearate, and lactose monohydrate.

Amlodipine-Lisinopril Mechanism

The combination works through two complementary mechanisms:

• Amlodipine blocks calcium entry into smooth muscle cells, relaxing the arteries and improving blood flow.

• Lisinopril inhibits the angiotensin-converting enzyme (ACE), reducing the formation of angiotensin II, a substance that tightens blood vessels and increases fluid retention.
  Together, they reduce vascular resistance and promote easier circulation, helping maintain steady blood pressure and decreasing heart workload.

How It Helps Control Blood Pressure and Heart Strain

This dual-action medicine helps control both systolic and diastolic pressure levels throughout the day. It reduces the frequency of chest pain (angina), prevents heart enlargement, and lowers the long-term risk of heart attack, stroke, and kidney damage associated with hypertension.

What Are Other Benefits

• Provides better blood pressure control with one pill, improving treatment convenience

• Helps protect kidney function, especially in people with diabetes or early kidney impairment

• Can reduce the need for multiple prescriptions and improve medication adherence

• Supports improved overall cardiovascular health and reduces hospital visits for heart-related complications

Dosages

Available Strengths or Dosage

Amlodipine-Lisinopril tablets are available in different fixed-dose combinations such as:

• Amlodipine 2.5 mg / Lisinopril 10 mg
• Amlodipine 5 mg / Lisinopril 5 mg
• Amlodipine 5 mg / Lisinopril 20 mg
• Amlodipine 10 mg / Lisinopril 40 mg

Your doctor will determine the appropriate dose based on your blood pressure level, age, and medical history.

How and When to Take It

• Take Amlodipine-Lisinopril tablets once daily, preferably at the same time each day.

• You may take it with or without food, but try to stay consistent with your routine.

• Swallow the tablet whole with water; do not crush or chew it.

• If you miss a dose, take it as soon as you remember, unless it’s almost time for your next one.

Overdose Caution

Taking more than the prescribed dose can cause excessive low blood pressure, dizziness, fainting, or irregular heartbeat. If overdose is suspected, seek emergency medical help immediately. Avoid combining this medicine with other blood pressure tablets or diuretics without consulting your doctor.

Who Can Use/Take Amlodipine-Lisinopril

This medication is suitable for adult men and women diagnosed with hypertension, heart failure, or cardiovascular disease.
However, it should be used cautiously or avoided in:

• Children and adolescents (unless prescribed by a specialist)

• Pregnant or breastfeeding women, as ACE inhibitors can harm the baby

• Patients with severe kidney or liver impairment

• Individuals with a history of angioedema or allergic reactions to ACE inhibitors

Side Effects & Precautions

What Are the Side Effects

Common side effects may include:

• Dizziness or lightheadedness, especially when standing up

• Swelling of ankles or feet (due to Amlodipine)

• Dry cough or throat irritation (common with Lisinopril)

• Headache, tiredness, or flushing
  Less common but serious side effects include:

• Severe low blood pressure or fainting

• Shortness of breath or chest pain

• Swelling of face, lips, or throat (angioedema)

• Changes in kidney function or high potassium levels in the blood

What Is the Precaution to Avoid Side Effects

• Monitor blood pressure and kidney function regularly while on treatment.

• Avoid salt substitutes or potassium-rich supplements unless advised by your doctor.

• Stand up slowly from sitting or lying positions to reduce dizziness.

• Limit alcohol intake, as it may enhance blood pressure-lowering effects.

• Notify your doctor if you experience persistent cough or swelling in the extremities.

• Pregnant women should discontinue use immediately if pregnancy occurs.

Always consult your cardiologist before starting or changing your dose. If prescribed, you can order Amlodipine-Lisinopril tablets online safely from trusted pharmacy sources and ensure timely refills to maintain your treatment progress.