Lidocaine-Prilocaine

What is Lidocaine-Prilocaine?

Lidocaine-Prilocaine is a topical anesthetic combination used to numb the skin before medical or cosmetic procedures. It helps reduce pain, burning, or discomfort by temporarily blocking nerve signals in the applied area. Available as a cream, gel, or topical preparation, this medicine is widely used across the USA for patients who need a reliable and gentle numbing effect.

Lidocaine-Prilocaine used for

Healthcare professionals use this topical anesthetic for:

• Minor dermatology procedures

• Needle insertions, blood draws, or vaccinations

• Skin laser treatments

• Tattoo or tattoo removal sessions

• Hair removal procedures

• Minor surgical procedures on the skin

It helps patients feel more comfortable and reduces anxiety during procedures.

Chemical composition

Each formulation contains two active ingredients:

• Lidocaine – an amide-type local anesthetic

• Prilocaine – another amide-type anesthetic that enhances numbing

Inactive ingredients may include water, emulsifiers, mineral oils, or stabilizers depending on the specific cream or gel brand.

Lidocaine-Prilocaine Mechanism

This combination works by blocking sodium channels in the skin’s nerve endings. When these channels are blocked, nerves cannot send pain signals to the brain. The result is temporary loss of sensation in the treated area, allowing medical procedures to be performed with minimal discomfort.

How does it help during procedures?

By numbing the upper layers of the skin, the cream helps reduce sharp sensations, stinging, or burning feelings during minor procedures. This makes processes like injections, dermatology treatments, or laser therapy easier to tolerate. It also helps children or sensitive patients remain calm during needle-related medical tasks.

What are the other benefits?

• Works within 30–60 minutes

• Reduces pain without needing oral medications

• Helpful for both medical and cosmetic uses

• Suitable for adults and children under medical guidance

• Non-invasive method of pain control

• Widely available in easy-to-apply topical forms

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Dosages

Available strengths or dosage

Lidocaine-Prilocaine commonly comes as:

• 2.5% Lidocaine + 2.5% Prilocaine cream

• Topical gel or patches containing the same concentration

Your doctor will recommend the appropriate amount based on the procedure and size of the treated area.

How and when to take it

• Apply the cream on clean, intact skin

• Use the recommended layer thickness—usually a thin, even coat

• Cover the area with an occlusive dressing if instructed

• Allow proper time for numbing (generally 30–60 minutes)

• Do not apply to broken, irritated, or eczematous skin unless directed

Avoid touching eyes or mouth after applying the cream.

Overdose caution

Using too much cream or applying it to large areas may cause:

• Skin irritation

• Dizziness

• Fast heartbeat

• Methemoglobinemia (rare but serious)

Seek medical help if unusual symptoms appear.

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Who can use/take Lidocaine-Prilocaine?

This topical anesthetic can be used by:

• Adults undergoing minor skin procedures

• Children when a doctor recommends it

• Individuals needing reduced discomfort during needle-related procedures

• Patients with anxiety about injections

Caution is necessary for:

• Infants below recommended age

• Pregnant or breastfeeding women (doctor guidance required)

• People with heart rhythm disorders

• Anyone with a known allergy to local anesthetics

• Individuals with G6PD deficiency (due to prilocaine-related risks)

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Side Effects & Precautions

What are the side effects?

Common side effects may include:

• Redness

• Mild swelling

• Temporary skin lightening or discoloration

• Warm or tingling feeling

• Itching at the application site

Rare but serious reactions can include breathing difficulty, dizziness, or bluish skin color.

What are the precautions to avoid side effects?

• Use only the amount prescribed

• Avoid applying on large or damaged skin areas

• Do not use heat sources over treated skin

• Keep away from mucous membranes

• Inform your doctor about any blood or enzyme disorders

• Follow recommended wait times before procedures

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Always consult your doctor before use. If prescribed, you can order Lidocaine-Prilocaine cream online safely from trusted pharmacy sources and ensure timely refills to maintain your treatment progress.