Leflunomide 20mg

Leflunomide 20mg Uses

Leflunomide 20mg is prescribed to:

• Treat rheumatoid arthritis by reducing inflammation and preventing joint damage.
• Manage psoriatic arthritis, an autoimmune condition affecting both skin and joints.
• Alleviate pain, swelling, and stiffness associated with autoimmune diseases.

How Does Leflunomide 20mg Work

Leflunomide inhibits the enzyme dihydroorotate dehydrogenase, which is necessary for the production of pyrimidines, key building blocks for DNA and RNA. By blocking this enzyme, it reduces the proliferation of activated immune cells responsible for inflammation, slowing the progression of autoimmune diseases.

How to Use Leflunomide 20mg

• Take Leflunomide 20mg exactly as prescribed by your healthcare provider, usually once daily.
• Swallow the tablet whole with water, with or without food.
• Follow your doctor’s instructions if starting with a loading dose.
• Regular blood tests are required to monitor liver function, kidney function, and blood counts during treatment.

Side Effects

Common side effects may include:

• Diarrhea
• Nausea or upset stomach
• Headache
• Mild hair thinning or loss

Rare but serious side effects include:

• Severe liver damage, with symptoms like jaundice (yellowing of the skin or eyes), dark urine, or persistent abdominal pain
• Bone marrow suppression, leading to unusual bleeding or bruising
• Severe skin reactions, such as Stevens-Johnson syndrome
• Increased susceptibility to infections due to immune suppression

Drug Interactions

Leflunomide 20mg may interact with:

• Immunosuppressants, which may increase the risk of infections.
• Methotrexate, which may amplify the risk of liver toxicity.
• Warfarin, which may require dose adjustments to prevent bleeding.
• Live vaccines, which should be avoided during treatment.

Food Interactions

• Leflunomide 20mg can be taken with or without food.
• Avoid alcohol, as it increases the risk of liver damage.

Leflunomide 20mg Contraindications

This medication is not suitable for:

• Individuals allergic to Leflunomide or any of its components.
• Pregnant women or those planning to conceive due to the risk of severe birth defects.
• Patients with severe liver impairment or a history of liver disease.

Precautions and Warnings

• Inform your doctor if you have a history of liver disease, kidney problems, or active infections.
• Women of childbearing age should use effective contraception during treatment and until the drug is completely cleared from the body.
• Leflunomide remains in the body for an extended period; a drug elimination procedure may be required for rapid clearance.
• Avoid contact with individuals who have contagious infections due to reduced immune response.

Storage

• Store Leflunomide 20mg tablets at room temperature, away from heat, moisture, and direct sunlight.
• Keep the tablets in their original packaging and out of reach of children and pets.
• Dispose of unused or expired tablets responsibly, following local disposal regulations.

Safety Information

• Use Leflunomide 20mg only as directed by your healthcare provider.
• Do not skip doses or stop taking the medication without consulting your doctor.
• Report any unusual symptoms, such as persistent diarrhea, jaundice, or signs of infection, to your healthcare provider immediately.