Zidovudine

What is Zidovudine

Zidovudine is a prescription antiretroviral medication used to treat and prevent HIV infection. It belongs to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). Zidovudine works by blocking HIV from multiplying in the body, helping maintain a stronger immune system. Patients often use Zidovudine as part of combination therapy to manage viral load and reduce the risk of HIV-related complications.

Zidovudine used for

• Treating HIV-1 infection in adults and children.

• Preventing mother-to-child transmission of HIV during pregnancy and childbirth.

• Reducing viral load to delay progression to AIDS.

• Supporting overall immune system health in patients living with HIV.

Chemical composition

Zidovudine is a synthetic nucleoside analogue. It incorporates into viral DNA during replication, terminating the DNA chain and preventing HIV from multiplying. This mechanism slows disease progression and lowers viral load, allowing the immune system to function more effectively.

Zidovudine Mechanism

Zidovudine selectively targets HIV reverse transcriptase, an enzyme essential for viral replication. By blocking this enzyme, it stops the virus from copying its genetic material, preventing further infection of healthy immune cells.

How it helps recovery

Regular use of Zidovudine helps patients maintain lower viral loads, improve immune function, and prevent opportunistic infections. When combined with other antiretroviral drugs, it helps manage HIV effectively, improves quality of life, and reduces hospitalizations related to infection.

Other benefits

• Reduces the risk of HIV transmission in high-risk populations.

• Enhances immune system response to prevent secondary infections.

• Helps maintain long-term viral suppression in combination therapy.

• Supports overall health and well-being for people living with HIV.

Dosages

Available strengths

Zidovudine is available in 100 mg and 300 mg tablets and oral solution forms. Dosage depends on patient age, weight, health status, and combination therapy regimen.

How and when to take it

Take Zidovudine orally with or without food, at the same times each day. Do not skip doses. For best results, follow your doctor’s instructions carefully and complete the prescribed course to maintain viral suppression.

Overdose caution

Overdose may cause nausea, vomiting, anemia, or severe fatigue. Seek immediate medical attention if an overdose occurs. Regular blood tests are essential to monitor red blood cell counts and liver function.

Who can use/take Zidovudine

Zidovudine is intended for adults, children, and pregnant women under strict medical supervision. Patients with liver disease, kidney issues, or a history of blood disorders should consult their doctor before use. Pregnant women benefit from Zidovudine to reduce the risk of mother-to-child transmission.

Zidovudine: Side Effects & Precautions

What are the side effects?

Common side effects include:

• Headache and dizziness

• Nausea, vomiting, or stomach upset

• Fatigue and weakness

• Muscle pain

Serious side effects (rare) may include:

• Severe anemia or neutropenia

• Liver toxicity

• Lactic acidosis

Precautions to avoid side effects

• Regular blood tests are required to monitor red and white blood cell counts.

• Avoid alcohol and medications that can increase liver strain.

• Inform your doctor of all other medications or supplements being taken.

• Report any unusual fatigue, bruising, or persistent nausea.

• Pregnant or breastfeeding women should follow medical guidance for safe use.

Zidovudine helps manage HIV infection, maintain immune health, and prevent virus progression. Consult your doctor before use.