Naltrexone

What is Naltrexone?

Naltrexone is a prescription medicine available in tablet and extended-release injection forms. It is not an opioid and does not create dependence, making it a trusted choice in addiction treatment programs. Many healthcare providers use it as part of a structured recovery plan to help individuals regain control over cravings and prevent relapse.

Naltrexone used for

Naltrexone is commonly prescribed for:

• Alcohol dependence

• Opioid use disorder

• Reducing cravings during recovery

• Preventing relapse in people previously dependent on opioids

• Supporting long-term sobriety plans

It is not used to treat opioid withdrawal, but rather to maintain stability after detox.

Chemical composition

Naltrexone contains the active ingredient Naltrexone Hydrochloride. Inactive components vary by manufacturer and may include cellulose, lactose, magnesium stearate, and coating agents in tablet form.

Naltrexone Mechanism

The medicine works by blocking opioid receptors in the brain. These receptors are responsible for creating the euphoric or “high” sensation caused by opioids or alcohol. By binding to these receptors without activating them, Naltrexone prevents rewarding effects, which helps reduce cravings and supports long-term recovery.

How does it help support recovery?

Naltrexone helps individuals by:

• Reducing the urge to drink alcohol

• Blocking the effects of opioids if used during treatment

• Helping people avoid relapse triggers

• Supporting mental clarity during recovery

• Allowing the brain to balance reward pathways over time

This approach improves treatment success, especially when combined with counseling and lifestyle support.

What are the other benefits?

• Non-addictive and not habit-forming

• Suitable for long-term maintenance therapy

• Helps maintain emotional stability

• Available in both daily tablet and monthly injection form

• Allows individuals to focus on social, work, and personal life improvements

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Dosages

Available strengths or dosage

Naltrexone is typically available as:

• 50 mg tablet

• Extended-release injection (once monthly)

The tablet is used on a daily schedule, while the injectable version provides steady levels for extended support.

How and when to take it

• Tablets are usually taken once daily, with or without food

• Follow your provider’s detox instructions before starting therapy

• Avoid opioids for at least 7–10 days prior to use

• Alcohol should be avoided during treatment

• Do not crush or split tablets unless approved

The injectable form is administered by a healthcare professional once every four weeks.

Overdose caution

Although overdose from oral tablets is rare, taking more than recommended can cause:

• Severe nausea

• Stomach pain

• Dizziness

• Confusion

• Unexpected liver effects

Avoid combining with opioids, as this can lead to dangerous reactions. Seek medical care if accidental overdose occurs.

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Who can use/take Naltrexone?

Naltrexone may be suitable for:

• Adults undergoing recovery from alcohol misuse

• Individuals who have completed opioid detox

• People committed to long-term relapse prevention

• Those seeking a non-addictive treatment option

Use with caution in people who have:

• Liver disease or hepatitis

• Kidney problems

• Severe withdrawal symptoms

• A recent history of opioid use

• Pregnancy or are breastfeeding

Children and adolescents should not use Naltrexone unless specifically recommended by a specialist.

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Side Effects & Precautions

What are the side effects?

Common side effects may include:

• Nausea or upset stomach

• Headache

• Tiredness

• Difficulty sleeping

• Joint or muscle pain

• Mild dizziness

Less common effects:

• Mood changes

• Skin rash

• Liver enzyme changes

• Injection site swelling (for injectable form)

Seek medical help if symptoms become severe or persistent.

What are the precautions to avoid side effects?

• Do not use opioids while taking Naltrexone

• Inform your provider about all current medicines

• Avoid alcohol during treatment for best results

• Complete opioid detox before starting

• Monitor liver function if used long term

• Avoid double-dosing to make up for missed pills

• Report any unusual pain or dark urine immediately

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Always consult your healthcare provider before starting treatment. If prescribed, you can order Naltrexone tablets online safely from trusted pharmacy sources and maintain a steady recovery plan with consistent use.