Valganciclovir
Valganciclovir is an L-valyl ester prodrug of Ganciclovir, used for the prevention and treatment of cytomegalovirus (CMV) disease, especially in transplant and HIV patients. It works by converting into Ganciclovir, which then potently inhibits viral DNA polymerase. This API offers significantly improved oral bioavailability over Ganciclovir, allowing for effective non-intravenous treatment. Valganciclovir is the standard oral agent for managing CMV infection.
What is Valganciclovir
Valganciclovir is an antiviral medication used to treat infections caused by cytomegalovirus (CMV), particularly in patients with weakened immune systems. It helps prevent viral replication, supporting the body in controlling the infection. This medicine reduces the severity and duration of CMV infections, aiding recovery and preventing complications in vulnerable patients.
Used for
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Treatment of CMV retinitis in patients with HIV/AIDS.
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Prevention of CMV infection in patients undergoing organ transplants.
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Reducing complications related to CMV in immunocompromised individuals.
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Supporting overall immune system function by controlling viral activity.
Chemical composition
The active compound converts into ganciclovir after ingestion. Ganciclovir interferes with viral DNA replication, which slows virus multiplication and helps the immune system fight the infection effectively.
Mechanism of action
After conversion to ganciclovir, the drug inhibits viral DNA polymerase. This stops the virus from replicating in infected cells, reducing symptoms and the risk of further spread. It helps maintain organ function in transplant patients and prevents vision loss in CMV retinitis.
How it helps recovery
By inhibiting viral replication, this treatment supports faster recovery, reduces viral load, and prevents disease progression. Regular use as prescribed minimizes complications and helps patients regain normal daily activity.
Other benefits
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Reduces the severity and duration of CMV infections.
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Helps prevent virus-related organ damage in transplant patients.
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Improves quality of life by controlling infection and related symptoms.
Dosages
Available strengths
Valganciclovir is available in 450 mg tablets. Dosage depends on the patient’s age, weight, and type of infection.
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CMV treatment: 900 mg twice daily for 21 days, followed by maintenance doses.
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CMV prevention (transplant patients): 900 mg once daily for several months.
How and when to take it
Take tablets orally with food to improve absorption. Swallow tablets whole with a full glass of water. Do not crush or chew the tablet. Follow your doctor’s instructions precisely to ensure safety and effectiveness.
Overdose caution
Overdose may cause nausea, vomiting, low blood counts, or kidney problems. Seek immediate medical attention in case of accidental overdose.
Who can use this medication
Valganciclovir is intended for adults and children as prescribed by a healthcare professional. Use with caution in patients with kidney impairment, low blood counts, or weakened immunity. Patients with a history of bone marrow disorders should consult their doctor before starting treatment.
Side Effects & Precautions
Side effects
Common side effects include:
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Nausea and vomiting
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Diarrhea
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Headache
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Fatigue
Serious side effects are rare but may involve low blood cell counts, kidney problems, or severe allergic reactions.
Precautions
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Regular blood tests are recommended to monitor for low white or red blood cells.
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Drink plenty of fluids to reduce kidney stress.
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Inform your doctor of all medications and medical conditions.
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Pregnant or breastfeeding women must consult a physician before use.
Valganciclovir helps control CMV infections, prevent complications, and support faster recovery. Consult your doctor before use. Order safely online only after prescription.