Alfacalcidol

What is Alfacalcidol?

Alfacalcidol is a synthetic vitamin D analogue used to manage and prevent bone disorders caused by calcium or phosphate imbalance. It helps improve bone strength by supporting calcium absorption and maintaining healthy bone density. Doctors often prescribe Alfacalcidol to patients with vitamin D deficiency, osteoporosis, renal osteodystrophy, and hypocalcemia related to chronic kidney disease.

Alfacalcidol Used For

Alfacalcidol is mainly used to treat conditions that arise due to calcium or phosphate imbalance, such as:

• Osteoporosis – improving bone density and reducing fracture risk.

• Renal Osteodystrophy – correcting vitamin D deficiency in kidney disorders.

• Hypocalcemia – increasing calcium levels in the blood.

• Rickets and Osteomalacia – promoting bone mineralization and reducing deformities.

Chemical Composition

The active ingredient is Alfacalcidol, a derivative of vitamin D₃ (cholecalciferol). It is usually formulated in capsules or oral solutions, with inactive components like glycerin, sorbitol, and purified water, depending on the manufacturer.

Alfacalcidol Mechanism

Once ingested, Alfacalcidol is converted in the liver to its active form, calcitriol. Calcitriol acts on the intestines, bones, and kidneys to regulate calcium and phosphate metabolism. It increases calcium absorption from the gut, minimizes calcium loss through urine, and helps maintain proper bone mineralization.

How It Helps to Restore Bone Health

By correcting vitamin D deficiency and improving calcium levels, Alfacalcidol ensures optimal bone formation and strength. It helps in reducing symptoms like bone pain, muscle weakness, and fatigue that occur in conditions like osteomalacia or chronic renal disease.

What Are Other Benefits

Besides improving bone health, Alfacalcidol may help:

• Enhance muscle strength and reduce fall risk in elderly patients.

• Support immune system functions.

• Improve quality of life for individuals with chronic kidney disease by maintaining mineral balance.

Dosages

Available Strengths or Dosage

Alfacalcidol is available in capsules, oral drops, and injections, with common strengths such as 0.25 mcg, 0.5 mcg, and 1 mcg. The dosage may vary based on the medical condition, age, and calcium levels in the blood.

How and When to Take It

Take Alfacalcidol capsules once daily, preferably at the same time each day, with or without food. For oral drops, use a dropper for accurate dosing. It’s important to follow the dosage exactly as prescribed by your doctor, as excessive vitamin D intake can lead to hypercalcemia.

Overdose Caution

An overdose of Alfacalcidol can cause high calcium levels (hypercalcemia), leading to nausea, vomiting, muscle weakness, and confusion. If you experience such symptoms, seek medical attention immediately. Never increase your dose without consulting your healthcare provider.

Who Can Use/Take Alfacalcidol

Alfacalcidol is generally prescribed for adults and elderly patients with vitamin D deficiency or bone metabolism disorders. It can also be used in children with rickets under pediatric supervision.

• Not recommended for individuals with high calcium levels or known hypersensitivity to vitamin D derivatives.

• Pregnant or breastfeeding women should use it only when clearly needed and under medical advice.

• Patients with kidney or liver disorders should follow the dose adjustments recommended by their physician.

Side Effects & Precautions

What Are the Side Effects

Common side effects of Alfacalcidol may include:

• Headache or dizziness

• Constipation or abdominal pain

• Loss of appetite

• Thirst or increased urination

• Mild skin rash

Serious but rare effects can include hypercalcemia, kidney stones, or heart rhythm disturbances due to elevated calcium levels. Report any unusual symptoms to your doctor promptly.

What Are the Precautions to Avoid Side Effects

• Regularly monitor calcium and phosphate levels through blood tests.

• Avoid taking additional vitamin D or calcium supplements without consulting your doctor.

• Maintain adequate hydration to prevent kidney complications.

• Inform your doctor about any other medications or supplements you are using, especially thiazide diuretics or antacids containing magnesium.

Always consult your healthcare provider before starting any dose. If prescribed, you can order Alfacalcidol capsules online safely from trusted pharmacy sources and ensure timely refills to maintain your treatment progress.