Nicoumalone 1mg Uses

Nicoumalone 1mg is prescribed for:

  • Preventing and treating venous thrombosis and its extension, as well as pulmonary embolism.
  • Managing and preventing stroke in patients with atrial fibrillation, particularly those who cannot take newer oral anticoagulants.
  • Preventing thromboembolic complications in patients with prosthetic heart valves.

How Does Nicoumalone 1mg Work

Nicoumalone is a vitamin K antagonist. It works by inhibiting the synthesis of vitamin K-dependent clotting factors, which are essential for blood clotting. By reducing these clotting factors, Nicoumalone helps thin the blood and prevent the formation of harmful clots.

How to Use Nicoumalone 1mg

  • Take Nicoumalone 1mg exactly as prescribed by your healthcare provider. The dose and duration will depend on your condition, age, and response to treatment.
  • It can be taken with or without food, but it is important to keep your intake of vitamin K consistent to avoid fluctuating effects.
  • Regular blood tests (INR test) are necessary to ensure your dose remains safe and effective.

Side Effects

Common side effects of Nicoumalone 1mg include:

  • Bleeding and bruising more easily than normal
  • Nausea
  • Diarrhea Serious side effects may include severe bleeding, liver problems, and allergic reactions. Immediate medical attention is needed if you experience unusual bleeding, black or bloody stools, severe abdominal pain, or yellowing of the skin or eyes.

Drug Interactions

Nicoumalone interacts with many other drugs, herbs, and foods. Some interactions can affect the way Nicoumalone works or increase your risk of bleeding. Notable interactions include:

  • Antibiotics
  • Antifungals
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Certain antidepressants
  • St. John’s Wort
  • Foods high in vitamin K (e.g., kale, spinach, and broccoli)

Contraindications

Nicoumalone is contraindicated in patients with:

  • Active major bleeding
  • Severe liver or kidney disease
  • Recent or upcoming surgery on the brain, spine, or eye
  • Pregnancy, particularly in the first and third trimesters

Precautions and Warnings

  • Regular monitoring of your blood’s clotting ability (INR level) is crucial.
  • Avoid activities that increase your risk of bleeding.
  • Inform doctors or dentists about your Nicoumalone use before any surgery or dental procedure.
  • Alcohol should be consumed in moderation as it can affect the medication’s effectiveness.

Storage

Store Nicoumalone 1mg at room temperature, away from light and moisture. Keep the medication in its original packaging, and ensure it is out of reach of children and pets.

Safety Information

It is vital to maintain regular contact with your healthcare provider and attend all scheduled appointments to monitor the medication’s effectiveness and adjust dosages as necessary.

Quantity 180, 270, 360, 90
Manufacturer Abbott
Indian Brand Acitrom 1mg
US Brand Name Acitrom, Nicoumalone
Generic Name Nicoumalone
Dosage 1mg
Drug Type Tablets
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