Uses of Mesalamine Enema 4gm/60ml

Mesalamine Enema 4gm/60ml is used to treat mild to moderate ulcerative colitis and proctosigmoiditis, reduce rectal and lower colon inflammation and associated symptoms, promote healing of the intestinal mucosa, and prevent flare-ups in chronic inflammatory bowel diseases.

How Does Mesalamine Enema 4gm/60ml Work?

Mesalamine works by inhibiting the production of inflammatory chemicals such as prostaglandins and leukotrienes in the intestinal lining. By targeting inflammation locally, it reduces swelling and irritation in the rectum and sigmoid colon, helping alleviate symptoms and promote healing. The rectal suspension ensures precise delivery to the affected area for maximum therapeutic effect.

How to Use Mesalamine Enema 4gm/60ml

Shake the bottle well before use to ensure the suspension is properly mixed. Lie on your left side with your left leg straight and your right leg bent toward your chest for easier administration. Remove the cap, lubricate the applicator tip, and gently insert it into the rectum. Squeeze the bottle slowly to release the medication and remove the applicator carefully. Retain the enema for as long as possible, preferably overnight, to allow maximum absorption. Use as directed by your healthcare provider, usually once daily at bedtime. If you miss a dose, apply it as soon as you remember unless it is close to your next scheduled dose. Do not double the dose to make up for a missed one.

Side Effects

Common side effects of Mesalamine Enema include rectal irritation, abdominal discomfort or cramping, nausea or gas, headache, and diarrhea. Rare but serious side effects include severe allergic reactions such as rash, swelling, or difficulty breathing, worsening of colitis symptoms, unusual bleeding or bruising, and kidney problems indicated by changes in urination. Seek immediate medical attention if you experience severe or persistent side effects.

Drug Interactions

Mesalamine Enema may interact with NSAIDs (e.g., Ibuprofen, Naproxen), which may increase the risk of kidney side effects, anticoagulants (e.g., Warfarin), which may increase the risk of bleeding, and immunosuppressants (e.g., Azathioprine, Mercaptopurine), which may increase the risk of bone marrow suppression. Always inform your healthcare provider about all medications, supplements, and herbal products you are using.

Food Interactions

There are no known significant food interactions with Mesalamine Enema. Maintaining a balanced diet and proper hydration can support overall gastrointestinal health during treatment.

Contraindications

Mesalamine Enema 4gm/60ml is contraindicated in individuals with known hypersensitivity to Mesalamine, Salicylates, or any other ingredients in the formulation, severe kidney or liver impairment without appropriate medical guidance, and intestinal obstruction or perforation. Your healthcare provider will evaluate your medical history to ensure the medication is safe for you.

Precautions and Warnings

Regular monitoring of kidney and liver function is recommended, particularly in individuals with pre-existing conditions. Use with caution in individuals with a history of hypersensitivity to salicylates or sulfasalazine. Consult your healthcare provider immediately if you experience severe abdominal pain, blood in the stool, or signs of worsening symptoms. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Mesalamine should be used with caution during these periods.

Safety Information

Seek immediate medical attention if you experience symptoms of severe allergic reactions, worsening colitis symptoms, or unusual bleeding or bruising. Overdose symptoms may include severe abdominal pain, diarrhea, or confusion. Contact a healthcare provider or poison control center immediately if overdose occurs.

Storage

Store Mesalamine Enema Rectal Suspension at room temperature, between 20–25°C (68–77°F). Keep the medication in a dry place, away from direct sunlight and excessive moisture. Avoid freezing the suspension. Ensure the medication is out of reach of children and pets. Dispose of unused or expired enemas responsibly, following local waste disposal guidelines.

Quantity 12, 3, 6, 9
Manufacturer Sun Pharma
Indian Brand Mesacol Enema 60ml
US Brand Name Mesalamine/Mesalazine
Generic Name Mesalamine/Mesalazine
Dosage 4gm-60ml
Drug Type Bottles
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