Pyrazinamide 750mg Uses

Pyrazinamide 750mg is prescribed for:

  • Active Tuberculosis (TB): Used in combination with other TB medications like rifampin, isoniazid, and ethambutol during the intensive phase of treatment to eliminate Mycobacterium tuberculosis.
  • Latent TB (Off-Label): In certain cases, may be used to treat latent TB as advised by a healthcare provider.

This higher-dose formulation is particularly effective in individuals requiring tailored dosage adjustments to ensure optimal TB control.

How Does Pyrazinamide 750mg Work?

Pyrazinamide is a prodrug activated in the body to pyrazinoic acid, which:

  • Inhibits Bacterial Growth: Disrupts energy production in Mycobacterium tuberculosis, weakening the bacteria and stopping their replication.
  • Targets Dormant Bacteria: Effectively acts on bacteria residing in acidic intracellular environments, addressing hard-to-reach bacterial populations.

This dual action enhances the overall effectiveness of multi-drug TB regimens.

How to Use Pyrazinamide 750mg

  1. Dosage: Take Pyrazinamide 750mg as prescribed by your doctor. Dosage is typically calculated based on body weight and the phase of TB treatment.
  2. Administration: Swallow the tablet whole with water. It can be taken with or without food.
  3. Timing: Follow the prescribed schedule consistently to ensure steady levels of the medication in your system.
  4. Adherence: Complete the entire course of treatment, even if symptoms improve, to prevent the development of drug-resistant TB strains.

Side Effects

Common side effects of Pyrazinamide 750mg include:

  • Nausea or vomiting
  • Loss of appetite
  • Stomach upset or discomfort
  • Joint pain (arthralgia)

Serious side effects, such as liver toxicity (hepatitis), jaundice, or allergic reactions, are rare but require immediate medical attention.

Drug Interactions

Pyrazinamide 750mg may interact with other medications. Inform your doctor if you are taking:

  • Rifampin, isoniazid, or other TB drugs
  • Medications affecting liver enzymes
  • Gout medications (e.g., allopurinol or colchicine), as Pyrazinamide may raise uric acid levels

Food Interactions

  • Meals: Pyrazinamide can be taken with or without food. Taking it with a meal or snack may help reduce stomach upset.
  • Alcohol: Avoid alcohol during treatment, as it may increase the risk of liver damage.

Contraindications

Pyrazinamide 750mg is contraindicated in individuals who:

  • Are allergic to Pyrazinamide or any of its components
  • Have severe liver disease or acute gout without medical supervision

Precautions and Warnings

  • Pregnancy and Breastfeeding: Consult your doctor before using Pyrazinamide if you are pregnant or breastfeeding. The medication is used if the benefits outweigh potential risks.
  • Liver Function: Regular monitoring of liver enzymes is necessary, as Pyrazinamide may cause liver toxicity.
  • Gout and Uric Acid Levels: Patients with a history of gout should inform their doctor, as Pyrazinamide may elevate uric acid levels, potentially triggering a gout flare.

Safety Information

  • Monitoring: Regular blood tests are recommended to check liver function and uric acid levels during treatment.
  • Medication Compliance: Adhering to the full treatment regimen is essential to avoid drug resistance and ensure effective TB control.
  • Lifestyle Considerations: Maintain a healthy lifestyle and avoid alcohol to reduce liver strain and support recovery.

Storage

  • Store Pyrazinamide 750mg at room temperature, away from heat, moisture, and direct sunlight.
  • Keep out of reach of children and pets.
  • Dispose of unused or expired medication responsibly.
Quantity 120, 30, 60, 90
Manufacturer Oaknet Healthcare Pvt Ltd
Indian Brand Pza ciba 750mg
US Brand Name PYRAZINAMIDE 750mg (pza)
Generic Name Pyrazinamide
Dosage 750mg
Drug Type Tablets
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