Pyrazinamide 500mg Uses

Pyrazinamide 500mg is prescribed for:

  • Tuberculosis (TB): Used as part of a multi-drug regimen to treat active tuberculosis, particularly during the intensive phase.
  • Latent TB (Off-Label): May be used in specific cases to treat latent TB, as recommended by a doctor.

Pyrazinamide 500mg is always used in combination with other TB medications, such as isoniazid and rifampin, to ensure complete eradication of the bacteria and prevent resistance.

How Does Pyrazinamide 500mg Work?

Pyrazinamide is a prodrug that becomes active once converted inside the body. It works by:

  • Inhibiting Bacterial Growth: Disrupts the energy production in Mycobacterium tuberculosis, weakening and killing the bacteria.
  • Targeting Dormant Bacteria: Acts on bacteria within acidic environments inside cells, effectively treating TB in tissues and organs.

This mechanism complements other TB medications, improving the overall treatment’s efficacy.

How to Use Pyrazinamide 500mg

  1. Dosage: Take Pyrazinamide 500mg exactly as prescribed by your doctor. Dosage depends on body weight and the specific TB treatment regimen.
  2. Administration: Swallow the tablet whole with water. It can be taken with or without food.
  3. Timing: Follow your doctor’s instructions for the timing and duration of therapy.
  4. Adherence: Complete the full course of treatment, even if symptoms improve, to prevent drug resistance and relapse.

Side Effects

Common side effects of Pyrazinamide 500mg include:

  • Nausea or vomiting
  • Loss of appetite
  • Stomach upset or discomfort
  • Joint pain (arthralgia)

Rare but severe side effects may include liver toxicity (hepatitis), yellowing of the skin or eyes (jaundice), or an allergic reaction. Contact your doctor immediately if you experience these symptoms.

Drug Interactions

Pyrazinamide 500mg may interact with other medications. Inform your doctor if you are taking:

  • Rifampin or other TB medications
  • Medications affecting liver enzymes
  • Drugs used for gout (e.g., allopurinol or colchicine), as Pyrazinamide may raise uric acid levels

Food Interactions

  • Meals: Pyrazinamide can be taken with or without food. If stomach upset occurs, consider taking it with a meal or snack.
  • Alcohol: Avoid alcohol during treatment, as it may increase the risk of liver damage.

Contraindications

Pyrazinamide 500mg is contraindicated in individuals who:

  • Are allergic to Pyrazinamide or any of its components
  • Have severe liver disease or acute gout without medical supervision

Precautions and Warnings

  • Pregnancy and Breastfeeding: Consult your doctor before using Pyrazinamide if you are pregnant or breastfeeding. The medication may be prescribed if the benefits outweigh potential risks.
  • Liver Function: Regular monitoring of liver enzymes is necessary, as Pyrazinamide may cause liver toxicity.
  • Gout and Uric Acid Levels: Inform your doctor if you have a history of gout, as Pyrazinamide can increase uric acid levels, potentially triggering an attack.

Safety Information

  • Monitoring: Regular blood tests to monitor liver function and uric acid levels are recommended throughout the treatment.
  • Medication Compliance: Adherence to the full TB treatment regimen is essential to avoid drug resistance and ensure successful treatment.
  • Lifestyle Considerations: Maintain a healthy lifestyle and avoid alcohol to reduce liver strain during therapy.

Storage

  • Store Pyrazinamide 500mg at room temperature, away from heat, moisture, and direct sunlight.
  • Keep out of reach of children and pets.
  • Dispose of unused or expired medication responsibly.
Quantity 120, 30, 60, 90
Manufacturer Lupin Ltd
Indian Brand Pyzina 500
US Brand Name Pyrazinamide
Generic Name Pyrazinamide
Dosage 500mg
Drug Type Tablets
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