Penicillin G Potassium 400mg Uses

Penicillin G Potassium 400mg is prescribed to:

  • Treat severe bacterial infections such as pneumonia, septicemia, and bacterial endocarditis.
  • Manage meningitis caused by susceptible bacterial strains.
  • Treat sexually transmitted infections, including syphilis and gonorrhea caused by penicillin-sensitive organisms.
  • Prevent rheumatic fever recurrence.
  • Manage anthrax, gas gangrene, and other severe infections caused by Clostridium species.

How Does Penicillin G Potassium 400mg Work

Penicillin G Potassium acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) within bacteria, disrupting cell wall construction and leading to bacterial cell lysis and death. This mechanism effectively clears the infection and prevents bacterial growth.

How to Use Penicillin G Potassium 400mg

  • Penicillin G Potassium 400mg is administered intravenously (IV) or intramuscularly (IM) by a healthcare professional.
  • The dosage and duration depend on the severity and type of infection being treated.
  • Complete the full course of treatment as prescribed, even if symptoms improve, to prevent the development of antibiotic resistance.

Side Effects

Common side effects may include:

  • Pain or irritation at the injection site
  • Nausea or vomiting
  • Diarrhea
  • Mild skin rash or itching

Rare but serious side effects include:

  • Severe allergic reactions, such as anaphylaxis (difficulty breathing, swelling, or hives)
  • Clostridium difficile-associated diarrhea
  • Neurotoxicity with high doses, such as seizures or confusion
  • Electrolyte imbalances due to the potassium content

Drug Interactions

Penicillin G Potassium 400mg may interact with:

  • Probenecid, which can increase blood levels of penicillin.
  • Methotrexate, potentially increasing the risk of toxicity.
  • Oral contraceptives, reducing their effectiveness.
  • Aminoglycosides, which may lose efficacy if mixed in the same IV line.

Food Interactions

  • No significant food interactions, as Penicillin G Potassium is administered parenterally.
  • Adequate hydration is recommended to support kidney function, especially when high doses are prescribed.

Penicillin G Potassium 400mg Contraindications

This medication is not suitable for:

  • Individuals with known allergies to penicillin or other beta-lactam antibiotics.
  • Patients with severe kidney dysfunction or electrolyte imbalances without proper monitoring.
  • Individuals with hypersensitivity to potassium.

Precautions and Warnings

  • Inform your doctor if you have a history of kidney disease, seizures, or heart conditions.
  • Use with caution in elderly patients and those at risk of electrolyte disturbances due to the potassium content.
  • Pregnant or breastfeeding women should consult their healthcare provider before receiving Penicillin G Potassium.
  • Regular monitoring of kidney function, electrolytes, and blood counts is recommended during treatment.

Storage

  • Store Penicillin G Potassium powder for injection at room temperature before reconstitution.
  • Once reconstituted, store as per healthcare provider instructions and use within the recommended timeframe.
  • Keep the medication out of reach of children and pets.

Safety Information

  • Use Penicillin G Potassium 400mg only as directed by a healthcare provider.
  • Do not discontinue treatment prematurely, as this may contribute to antibiotic resistance.
  • Report any severe side effects, such as allergic reactions or neurological symptoms, to your doctor immediately.
Quantity 120, 180, 240, 60
Manufacturer Abbott
Indian Brand Pentids 400
US Brand Name Penicillin G Potassium
Generic Name Penicillin G Potassium
Dosage 400mg
Drug Type Tablets
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