Sorafenib 200mg Uses

Sorafenib 200mg is prescribed to:

  • Treat advanced liver cancer (hepatocellular carcinoma) in patients who are not eligible for surgical treatment.
  • Manage advanced kidney cancer (renal cell carcinoma) when other treatments are not effective.
  • Treat differentiated thyroid cancer that has progressed and is unresponsive to radioactive iodine therapy.

How Does Sorafenib 200mg Work

Sorafenib works by inhibiting multiple kinases, which are enzymes that promote the growth and division of cancer cells. It also blocks the development of new blood vessels (angiogenesis) that tumors need to grow. This dual action slows tumor growth, reduces its spread, and shrinks existing tumors.

How to Use Sorafenib 200mg

  • Take Sorafenib 200mg exactly as prescribed by your healthcare provider, typically twice daily (12 hours apart).
  • Swallow the tablet whole with water, on an empty stomach, at least 1 hour before or 2 hours after a meal.
  • Do not crush, chew, or break the tablet.
  • Follow your doctor’s instructions carefully, and do not adjust the dose without consultation.

Side Effects

Common side effects may include:

  • Fatigue or weakness
  • Diarrhea, nausea, or vomiting
  • Hand-foot skin reaction (redness, pain, or peeling on the palms or soles)
  • Hair thinning or rash
  • High blood pressure

Rare but serious side effects include:

  • Severe bleeding, including gastrointestinal bleeding
  • Heart problems, such as heart attack or irregular heartbeat
  • Liver dysfunction, with symptoms like yellowing of the skin or eyes (jaundice)
  • Severe skin reactions, including blisters or peeling

Drug Interactions

Sorafenib 200mg may interact with:

  • Certain antibiotics or antifungals that affect liver enzymes, altering Sorafenib levels.
  • Blood-thinning medications (e.g., warfarin) that may increase the risk of bleeding.
  • Drugs used for seizures, such as phenytoin or carbamazepine, which may reduce Sorafenib effectiveness.
  • Herbal supplements like St. John’s Wort, which can decrease Sorafenib levels.

Food Interactions

  • Avoid consuming grapefruit or grapefruit juice, as it can interfere with Sorafenib metabolism.
  • Maintain a balanced diet to manage potential side effects, such as fatigue or diarrhea.

Sorafenib 200mg Contraindications

This medication is not suitable for:

  • Individuals allergic to Sorafenib or any of its components.
  • Pregnant or breastfeeding women, as Sorafenib can harm the fetus or infant.
  • Patients with severe liver or kidney dysfunction unless specifically advised by a healthcare provider.

Precautions and Warnings

  • Inform your doctor if you have a history of heart disease, high blood pressure, or bleeding disorders.
  • Regular monitoring of liver function, blood pressure, and complete blood counts is essential during treatment.
  • Women of childbearing potential must use effective contraception during treatment and for at least 6 months after discontinuing Sorafenib.
  • Avoid activities that may increase the risk of cuts or bruises, as Sorafenib may affect blood clotting.

Storage

  • Store Sorafenib 200mg tablets at room temperature, away from moisture, heat, and direct light.
  • Keep the medication in its original packaging and out of reach of children and pets.
  • Dispose of unused or expired tablets responsibly, following local disposal regulations.

Safety Information

  • Use Sorafenib 200mg only as directed by your healthcare provider.
  • Do not adjust the dosage or discontinue the medication without consulting your doctor.
  • Report any unusual symptoms, such as severe bleeding, chest pain, or signs of liver dysfunction, to your healthcare provider immediately.
Quantity 120, 30, 60, 90
Manufacturer Cipla Limited
Indian Brand Soranib
US Brand Name Nexavar | Sorafenib
Generic Name Sorafenib
Dosage 200mg
Drug Type Tablets
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