Clozapine 25mg Uses

Clozapine 25mg is prescribed to:

  • Treat schizophrenia in patients who are unresponsive to standard antipsychotic treatments.
  • Reduce the risk of suicidal behaviors in patients with schizophrenia or schizoaffective disorders who are at chronic risk.

How Clozapine 25mg Works

Clozapine works by affecting the action of neurotransmitters in the brain, particularly dopamine and serotonin, which are involved in schizophrenia’s symptomatology. Unlike other antipsychotics, clozapine binds to several different dopamine receptors with varying affinity, which is thought to contribute to its effectiveness and unique profile, particularly in reducing the risk of extrapyramidal symptoms and improving negative symptoms of schizophrenia.

How to Use Clozapine 25mg

  • Clozapine 25mg should be taken orally, with or without food, usually once or twice daily as directed by your healthcare provider.
  • Dosage is based on your medical condition, response to treatment, and other medications you may be taking.
  • Be sure to follow your doctor’s instructions carefully. Start with a lower dose to decrease the risk of side effects, and gradually increase it as directed by your doctor.
  • Regular blood tests are required to monitor your progress and check for side effects.

Side Effects

Common side effects of Clozapine include:

  • Drowsiness
  • Dizziness
  • Constipation
  • Dry mouth
  • Weight gain

Serious side effects that require immediate medical attention include:

  • Seizures
  • Severe dizziness
  • Fainting
  • Fast/irregular heartbeat
  • Signs of infection (such as fever, persistent sore throat)
  • Unusual tiredness or weakness

Drug Interactions

Clozapine can interact with:

  • Other antipsychotic medications
  • Anticholinergics (such as benztropine, trihexyphenidyl)
  • Certain antidepressants
  • Benzodiazepines
  • Blood pressure medications

Inform your doctor about all medications and supplements you are currently taking, as they may need to adjust dosages or take precautions.

Precautions and Warnings

  • Blood Monitoring: Clozapine can cause a decrease in white blood cells, which can lead to severe infection. Regular blood tests (as often as once a week) are mandatory to monitor your blood cell counts.
  • Cardiovascular Health: Use with caution in patients with cardiovascular and cerebrovascular diseases due to an increased risk of stroke or heart problems.
  • Seizure Risk: Inform your doctor if you have a history of seizures, as clozapine can increase the risk of seizures.

Storage

Store Clozapine 25mg at room temperature, away from light and moisture. Do not store in the bathroom. Keep all medications out of reach of children and pets.

Clozapine 25mg is a critical medication in the management of treatment-resistant schizophrenia and suicidal behaviors associated with psychiatric disorders. Adherence to treatment protocols, including regular blood monitoring and dose adjustments based on clinical response, is essential for safe and effective use.

Quantity 120, 30, 60, 90
Manufacturer Sun Pharma
Indian Brand Sizopin 25mg
US Brand Name Clozapine
Generic Name Clozapine
Dosage 25mg
Drug Type Tablets

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