Carbidopa-Levodopa 25mg-250mg CR Uses

Carbidopa-Levodopa 25mg-250mg CR is prescribed for:

  • Parkinson’s Disease: Effectively manages motor symptoms like rigidity, tremors, and bradykinesia (slowness of movement).
  • Parkinsonism: Treats Parkinson-like symptoms caused by other medical conditions or medications.

The controlled-release formulation offers sustained symptom management, making it an ideal choice for patients requiring long-lasting effects.

How Does Carbidopa-Levodopa 25mg-250mg CR Work?

Carbidopa-Levodopa 25mg-250mg CR combines two active ingredients:

  • Levodopa: Converts into dopamine in the brain to replenish low levels, improving motor function and reducing symptoms.
  • Carbidopa: Prevents the breakdown of Levodopa in the bloodstream, enhancing its delivery to the brain and reducing side effects like nausea.

The controlled-release formulation ensures a gradual release of the medication, minimizing fluctuations in dopamine levels and providing consistent relief from symptoms throughout the day.

How to Use Carbidopa-Levodopa 25mg-250mg CR

  1. Dosage: Take Carbidopa-Levodopa 25mg-250mg CR as prescribed by your healthcare provider. The dosage will depend on your condition and response to treatment.
  2. Administration: Swallow the tablet whole with water; do not crush, chew, or break it, as this will disrupt the controlled-release mechanism.
  3. Timing: Take the medication at the same times each day to maintain steady drug levels.
  4. Food: You can take it with or without food, but avoid high-protein meals near dosing as they may interfere with absorption.

Side Effects

Common side effects of Carbidopa-Levodopa 25mg-250mg CR include:

  • Nausea or vomiting
  • Drowsiness or dizziness
  • Dry mouth
  • Lightheadedness
  • Involuntary movements (dyskinesia)

In rare cases, severe side effects such as hallucinations, confusion, mood changes, or irregular heartbeats may occur. Contact your healthcare provider immediately if these symptoms arise.

Drug Interactions

Carbidopa-Levodopa 25mg-250mg CR may interact with other medications, altering its effectiveness or increasing the risk of side effects. Inform your doctor if you are taking:

  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • Antipsychotic medications
  • Iron supplements (may reduce absorption)
  • Blood pressure medications

Food Interactions

Avoid high-protein meals while taking Carbidopa-Levodopa 25mg-250mg CR, as protein can interfere with the absorption of Levodopa. Space your protein intake evenly throughout the day for optimal effectiveness of the medication.

Contraindications

Carbidopa-Levodopa 25mg-250mg CR is contraindicated in individuals who:

  • Are allergic to Carbidopa, Levodopa, or any other ingredients in the medication
  • Have narrow-angle glaucoma
  • Are taking non-selective MAO inhibitors

Precautions and Warnings

  • Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to conceive, or breastfeeding, as the medication may affect the baby.
  • Sudden Discontinuation: Do not stop taking the medication abruptly, as it may worsen Parkinson’s symptoms or cause withdrawal effects.
  • Driving and Machinery: Avoid activities requiring mental alertness, such as driving, until you understand how the medication affects you.
  • Monitoring: Regular check-ups are necessary to adjust the dosage and monitor for side effects.

Storage

Store Carbidopa-Levodopa 25mg-250mg CR at room temperature, away from moisture, heat, and direct sunlight. Keep the medication out of reach of children and pets. Dispose of expired or unused tablets responsibly.

Quantity 120, 30, 60, 90
Manufacturer Sun Pharma
Indian Brand Syndopa 275mg
US Brand Name Carbidopa-Levodopa, Sinemet
Generic Name Carbidopa-Levodopa
Dosage 25mg-250mg
Drug Type Tablets
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