Sildenafil Citrate Tablets

What is Sildenafil Citrate?

Sildenafil Citrate is a prescription medication belonging to the phosphodiesterase type 5 (PDE5) inhibitor drug class. It is primarily approved to treat erectile dysfunction (ED) in adult men and pulmonary arterial hypertension (PAH) in both men and women.

Approved and commonly prescribed uses include:

• Erectile dysfunction (inability to achieve or maintain an erection)
• Pulmonary arterial hypertension (PAH) — to improve exercise capacity and delay clinical worsening

Available formulations and strengths:

• Sildenafil Citrate 25mg
• Sildenafil Citrate 50mg
• Sildenafil Citrate 100mg
• Sildenafil Citrate 100mg CT Tablets (Viagra Mint Flavored)
• Sildenafil Citrate 100mg Sublingual
• Sildenafil Citrate Green 100mg
• Sildenafil Citrate Soft 100mg Chewable Tablets (4 Flavors)
• Sildenafil Citrate Oral Jelly 100mg ( 7 Flavors )
• Sildenafil Citrate Oral Jelly 100mg-5gm (1 Week Pack)
• Sildenafil Citrate 100mg Effervescent Tablets (Orange
• Sildenafil Citrate 120mg
• Sildenafil Citrate 150mg

What is the Recommended Dosage of Sildenafil Citrate?

Dosage varies depending on the condition being treated, the patient’s age, overall health, kidney or liver function, and how the individual responds to treatment.

For erectile dysfunction: Dosing is typically taken as needed, before anticipated sexual activity. The starting dose and any adjustments are determined by a licensed physician.

For pulmonary arterial hypertension: Dosing is usually scheduled at fixed intervals throughout the day, as directed by a specialist.

Available dosage forms: 25 mg, 50 mg, and 100 mg tablets (ED); 20 mg tablets and oral suspension (PAH).

All dosing must follow the instructions of a licensed medical specialist. Patients should never self-adjust their dose without consulting their doctor.

How Sildenafil Citrate Works

Sildenafil Citrate works by blocking an enzyme called phosphodiesterase type 5 (PDE5). This enzyme normally breaks down a chemical called cyclic GMP (cGMP), which helps relax and widen blood vessels.

In erectile dysfunction: By blocking PDE5, sildenafil allows cGMP to build up, which relaxes the smooth muscle in the penis and increases blood flow when a person is sexually aroused. It does not cause an erection on its own — sexual stimulation is required.

In pulmonary arterial hypertension: The same mechanism relaxes the blood vessels in the lungs, reducing pressure and making it easier for the heart to pump blood. This helps improve exercise ability and reduces symptoms.

Sildenafil manages these conditions but does not cure the underlying cause. Ongoing use and medical monitoring are typically required.

Is a Prescription Required to Buy Sildenafil Citrate Online?

Yes. Sildenafil Citrate is a prescription-only medication in most countries, including the United States, the United Kingdom, Canada, and across the European Union.

Patients should consult a licensed medical specialist before obtaining this medication:

• Urologist or men’s health specialist — for erectile dysfunction
• Pulmonologist or cardiologist — for pulmonary arterial hypertension

When ordering online, patients must use verified, licensed pharmacies that require a valid prescription. Counterfeit sildenafil tablets are widely circulated online and may contain incorrect doses, harmful ingredients, or no active substance at all. Veterinary formulations of sildenafil exist and are not safe or appropriate for human use. Always purchase from a licensed, regulated pharmacy.

Side Effects of Sildenafil Citrate

Common Side Effects

These are generally mild and may improve as the body adjusts to the medication:

• Headache
• Facial flushing (warmth or redness of the face)
• Nasal congestion or runny nose
• Upset stomach or indigestion
• Dizziness or lightheadedness
• Temporary visual changes (such as mild blurred vision or a bluish tint to vision)
• Back pain or muscle aches

Serious Side Effects

Although rare, the following require immediate medical attention:

• Sudden vision loss in one or both eyes (a condition called NAION — non-arteritic anterior ischemic optic neuropathy)
• Sudden hearing loss or ringing in the ears
• Priapism — a prolonged, painful erection lasting more than 4 hours (seek emergency care immediately)
• Severe drop in blood pressure, especially when combined with nitrates
• Chest pain, irregular heartbeat, or signs of a heart attack
• Severe allergic reaction (hives, difficulty breathing, swelling of the face, lips, or throat)

Patients experiencing any serious symptoms should stop taking the medication and contact emergency medical services or their doctor right away.

Drug Interactions

Sildenafil Citrate has several important drug interactions that patients and caregivers must be aware of.

Medications that may interact include:

• Nitrates (e.g., nitroglycerin, isosorbide) — used for chest pain. Combining these with sildenafil can cause a dangerous, potentially life-threatening drop in blood pressure. This combination is contraindicated.
• Alpha-blockers (e.g., doxazosin, tamsulosin) — used for high blood pressure or prostate conditions. May increase the risk of low blood pressure.
• Other PDE5 inhibitors (e.g., tadalafil, vardenafil) — should not be combined with sildenafil.
• Antifungal medications (e.g., ketoconazole, itraconazole) — may increase sildenafil blood levels.
• HIV protease inhibitors (e.g., ritonavir) — can significantly increase sildenafil levels in the body.
• Certain antibiotics (e.g., erythromycin, clarithromycin)
• Blood pressure medications of various classes

Over-the-counter medications: Some OTC decongestants and pain relievers may interact. Always inform your doctor.

Supplements and herbal products: St. John’s Wort may reduce sildenafil effectiveness. Grapefruit and grapefruit juice may increase sildenafil levels in the blood and should generally be avoided.

Patients must provide their licensed medical specialist with a complete list of all prescription medications, over-the-counter drugs, vitamins, and supplements they are currently taking.

Safety & Important Considerations

Cardiovascular health: Sexual activity places demands on the heart. Patients with a history of heart attack, stroke, serious arrhythmia, or uncontrolled hypertension should discuss the risks carefully with their doctor before using sildenafil.

Low blood pressure: Sildenafil can lower blood pressure. Patients with pre-existing low blood pressure should use it only under close medical supervision.

Liver or kidney disease: Patients with significant liver or kidney impairment may require dose adjustments. Inform your doctor about any organ function concerns.

Pregnancy and breastfeeding: Sildenafil is not approved for use in women for ED. For PAH, its use during pregnancy or breastfeeding requires careful evaluation of risks and benefits by a specialist. Patients who are pregnant or breastfeeding should discuss this with their doctor.

Age-related considerations: Older adults may be more sensitive to the effects of sildenafil. Dose adjustments may be appropriate and should be guided by a physician. Sildenafil is not approved for use in children for ED; its use in children for PAH must be closely supervised by a specialist.

Monitoring: Patients on sildenafil for PAH typically require regular monitoring of blood pressure, heart function, and exercise capacity. For ED, routine follow-up is recommended.

FDA Safety Warnings: The FDA has issued warnings about the risk of serious vision and hearing loss, as well as the danger of combining sildenafil with nitrates. Patients should review these warnings with their healthcare provider.

Who This Medication Is For

Sildenafil Citrate is intended for:

• Adult men diagnosed with erectile dysfunction who have undergone a proper medical evaluation
• Adult men and women diagnosed with pulmonary arterial hypertension (WHO Group I), requiring pharmacological management to improve exercise capacity and slow disease progression

The medication is appropriate for individuals whose condition has been clinically confirmed by a licensed specialist and who do not have contraindications to its use.

Who Should Not Take Sildenafil Citrate

Sildenafil Citrate is contraindicated or should be used with extreme caution in:

• Patients currently taking nitrates in any form (including recreational nitrite inhalants known as “poppers”)
• Patients with a known allergy or hypersensitivity to sildenafil or any component of the formulation
• Patients with severe cardiovascular disease or those for whom sexual activity is inadvisable
• Patients with severe liver impairment
• Patients with a recent history of stroke or heart attack (within the last 6 months), unless cleared by a cardiologist
• Patients with hereditary degenerative retinal disorders such as retinitis pigmentosa
• Patients with severe hypotension (low blood pressure)
• Patients taking riociguat (a medication used for pulmonary hypertension) — this combination is contraindicated
• Patients taking certain antiretroviral medications may require dose modifications or complete avoidance

This list is not exhaustive. A licensed medical specialist must evaluate each patient individually before prescribing sildenafil.

What to Do If You Miss a Dose

For erectile dysfunction (taken as needed): Since sildenafil for ED is taken only before sexual activity and not on a fixed schedule, a “missed dose” scenario generally does not apply. Do not take more than one dose in a 24-hour period.

For pulmonary arterial hypertension (scheduled dosing): If a scheduled dose is missed, take it as soon as you remember — unless it is close to the time of your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

If you are unsure what to do after missing a dose, contact your licensed medical specialist or pharmacist for guidance.

Alternatives to Sildenafil Citrate

Several other medications are used in the same therapeutic class or for similar indications. These include:

• Tadalafil (Cialis) — a PDE5 inhibitor used for both ED and PAH; known for a longer duration of action
• Vardenafil (Levitra, Staxyn) — a PDE5 inhibitor used for ED
• Avanafil (Stendra) — a PDE5 inhibitor used for ED with a faster onset profile
• Bosentan and Ambrisentan — endothelin receptor antagonists used specifically for PAH
• Riociguat (Adempas) — a soluble guanylate cyclase stimulator used for PAH (note: cannot be combined with sildenafil)
• Alprostadil — used for ED via injection or urethral suppository when oral medications are not suitable

Switching from sildenafil to any alternative treatment must always be done under the direct supervision of a qualified medical specialist. Patients should never switch medications on their own.

Storage Instructions

• Store sildenafil citrate tablets at room temperature, typically between 59°F and 86°F (15°C to 30°C)
• Keep the medication away from moisture and humidity — do not store in bathrooms or near kitchen sinks
• Protect from direct sunlight and heat
• Keep in the original packaging or a tightly closed container
• Store out of reach of children and pets at all times
• Do not use the medication past its expiration date
• Dispose of unused or expired medication safely — follow local pharmacy take-back programs or disposal guidelines

Frequently Asked Questions (FAQs)

What is the cost of Sildenafil Citrate Tablets without insurance?

The cost without insurance depends on the seller, brand availability, and pack size, and may also vary by location and applicable discounts. Generic sildenafil is generally considered more affordable compared to brand-name versions. Patients are encouraged to compare prices at licensed pharmacies and ask about available savings programs.

How can I order Sildenafil Citrate Tablets online?

A valid prescription from a licensed healthcare provider is required to order sildenafil citrate online. The typical process involves uploading your prescription to a verified online pharmacy — or having your doctor send it directly — followed by home delivery. Always use a licensed, regulated pharmacy to avoid counterfeit or substandard products.

Is Sildenafil Citrate available over the counter?

Sildenafil Citrate is not available over the counter in most countries, including the United States and the United Kingdom. Regulations may vary by region, but medical supervision is generally required due to the potential for serious drug interactions and cardiovascular risks.

Disclaimer:

This page is provided for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Patients and caregivers must consult a licensed medical specialist such as a urologist, men’s health physician, pulmonologist, or cardiologist, depending on the condition being treated  before starting, changing, or stopping treatment with sildenafil citrate. Read more about our medical disclaimer policy