Perindopril-Indapamide 4mg-1.25mg

Perindopril-Indapamide 4mg-1.25mg Uses

Perindopril-Indapamide 4mg-1.25mg is prescribed to:

• Treat hypertension (high blood pressure) in patients requiring dual therapy.
• Reduce the risk of heart attack, stroke, and other cardiovascular events.
• Improve heart function in patients with co-existing heart conditions.
• Protect kidney health in conditions related to high blood pressure.

How Does Perindopril-Indapamide 4mg-1.25mg Work

• Perindopril: As an ACE inhibitor, it relaxes blood vessels by inhibiting the conversion of angiotensin I to angiotensin II, a chemical that causes blood vessel constriction. This improves blood flow and lowers blood pressure.
• Indapamide: A thiazide-like diuretic that helps remove excess sodium and water through the kidneys, reducing blood volume and blood pressure.

The combination provides enhanced blood pressure control by addressing different mechanisms.

How to Use Perindopril-Indapamide 4mg-1.25mg

• Take Perindopril-Indapamide 4mg-1.25mg exactly as prescribed by your healthcare provider, usually once daily in the morning.
• Swallow the tablet whole with a glass of water, with or without food.
• Take the medication consistently at the same time each day.
• Do not stop taking the medication abruptly without consulting your doctor, even if you feel well.

Side Effects

Common side effects may include:

• Dizziness or lightheadedness
• Headache
• Fatigue or weakness
• Nausea or upset stomach
• Dry cough (associated with ACE inhibitors)

Rare but serious side effects include:

• Severe allergic reactions, such as angioedema (swelling of the face, lips, or throat)
• Electrolyte imbalances, causing muscle weakness or irregular heartbeat
• Severe hypotension (low blood pressure)
• Kidney or liver dysfunction

Drug Interactions

Perindopril-Indapamide 4mg-1.25mg may interact with:

• Potassium supplements or potassium-sparing diuretics, increasing the risk of hyperkalemia (high potassium levels).
• Nonsteroidal anti-inflammatory drugs (NSAIDs), which may reduce the effectiveness of Perindopril.
• Lithium, as Indapamide can increase lithium levels and risk of toxicity.
• Other blood pressure medications, which may cause excessive lowering of blood pressure.

Food Interactions

• Avoid potassium-rich foods and salt substitutes containing potassium to prevent hyperkalemia.
• Limit alcohol consumption, as it may increase the risk of dizziness or fainting.

Perindopril-Indapamide 4mg-1.25mg Contraindications

This medication is not suitable for:

• Individuals allergic to Perindopril, Indapamide, or other sulfonamides.
• Patients with a history of angioedema related to ACE inhibitor use.
• Pregnant or breastfeeding women, as it may harm the baby.
• Individuals with severe kidney or liver impairment or low potassium levels.

Precautions and Warnings

• Inform your doctor if you have a history of kidney or liver disease, heart conditions, or electrolyte imbalances.
• Regular monitoring of blood pressure, kidney function, and electrolyte levels is recommended during treatment.
• Avoid sudden changes in posture to reduce the risk of dizziness or fainting.
• Notify your healthcare provider of any upcoming surgeries or anesthesia use.

Storage

• Store Perindopril-Indapamide 4mg-1.25mg tablets at room temperature, away from moisture, heat, and direct sunlight.
• Keep the tablets in their original packaging and out of reach of children and pets.
• Dispose of unused or expired tablets responsibly, following local disposal guidelines.

Safety Information

• Use Perindopril-Indapamide 4mg-1.25mg only as directed by your healthcare provider.
• Do not exceed the prescribed dose or discontinue use without medical advice.
• Report any unusual symptoms, such as persistent cough, swelling, or severe dizziness, to your doctor immediately.