Indomethacin 75mg SR Tablets

Uses of Indomethacin 75mg SR Tablets

Indomethacin 75mg SR Tablets are used for:

• Arthritis: Relieves pain, stiffness, and inflammation caused by conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Acute Gout Attacks: Reduces inflammation and alleviates pain associated with gout flare-ups.
• Bursitis and Tendonitis: Eases pain and swelling in the joints and tendons.
• Mild to Moderate Pain: Manages pain due to injuries, surgeries, or other inflammatory conditions.

This medication provides symptomatic relief but does not cure the underlying condition.

How Does Indomethacin 75mg SR Work?

Indomethacin is a potent NSAID that works by:

• Inhibiting the production of prostaglandins, chemicals in the body responsible for causing pain, fever, and inflammation.
• Reducing swelling, redness, and discomfort in the affected areas.

The sustained-release formulation ensures consistent therapeutic levels of the medication, providing prolonged relief.

How to Use Indomethacin 75mg SR Tablets

• Dosage: The usual dose is one tablet (75mg) once daily. In some cases, your doctor may recommend splitting the dose into two administrations per day.
• Administration: Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
• Timing: Take the medication with food or milk to reduce the risk of stomach irritation.
• Missed Dose: If you forget a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose. Do not double the dose to make up for the missed one.

Always follow your healthcare provider’s instructions for optimal results.

Side Effects

Common side effects of Indomethacin 75mg SR Tablets include:

• Nausea, vomiting, or indigestion
• Heartburn or abdominal discomfort
• Drowsiness or dizziness
• Headache
• Constipation or diarrhea

Rare but serious side effects include:

• Gastrointestinal bleeding or ulcers, with symptoms such as black or tarry stools or vomiting blood
• Liver or kidney dysfunction, indicated by yellowing of the skin or eyes (jaundice) or changes in urination
• Severe allergic reactions, such as rash, swelling, or difficulty breathing
• Cardiovascular events, such as chest pain or shortness of breath

Seek immediate medical attention if you experience severe or persistent side effects.

Drug Interactions

Indomethacin 75mg SR Tablets may interact with other medications, potentially increasing the risk of side effects or altering drug efficacy. Common interactions include:

• Anticoagulants (e.g., Warfarin): Increased risk of bleeding.
• Diuretics: Reduced effectiveness of diuretics and increased risk of kidney problems.
• ACE Inhibitors and ARBs (e.g., Lisinopril, Losartan): May decrease the effectiveness of these medications and worsen kidney function.
• Corticosteroids: Increased risk of gastrointestinal side effects.
• SSRIs (e.g., Fluoxetine): Elevated risk of gastrointestinal bleeding.

Inform your healthcare provider about all medications, supplements, or herbal products you are taking.

Food Interactions

Indomethacin should be taken with food or milk to minimize stomach irritation. Avoid:

• Alcohol: Can increase the risk of stomach ulcers and bleeding.
• Caffeine: Excessive consumption may exacerbate gastrointestinal discomfort.

Consult your doctor for any specific dietary restrictions.

Contraindications

Indomethacin 75mg SR Tablets are contraindicated in the following cases:

• Known allergy to Indomethacin, NSAIDs, or any ingredients in the formulation.
• History of asthma, urticaria, or allergic reactions triggered by NSAIDs.
• Active or recent gastrointestinal bleeding, ulcers, or perforation.
• Severe liver or kidney impairment.
• Pregnancy, especially during the third trimester, or breastfeeding.

Your doctor will evaluate your medical history to determine if this medication is suitable for you.

Precautions and Warnings

• Cardiovascular Risk: Prolonged use of NSAIDs may increase the risk of heart attack or stroke, particularly in patients with pre-existing heart conditions.
• Gastrointestinal Risk: This medication can cause stomach ulcers, bleeding, or perforation, particularly in older adults or those with a history of gastrointestinal issues.
• Kidney and Liver Monitoring: Regular tests may be needed to monitor kidney and liver function during long-term use.
• Pregnancy and Breastfeeding: Avoid use unless specifically directed by a healthcare provider.
• Driving and Machinery: Avoid activities requiring alertness if you experience dizziness or drowsiness.

Safety Information

• Emergency Situations: Seek immediate medical attention if you experience severe allergic reactions, signs of gastrointestinal bleeding, or chest pain.
• Overdose: Symptoms of overdose include severe abdominal pain, vomiting, confusion, or seizures. Contact your healthcare provider or poison control center immediately in case of overdose.
• Regular Follow-Ups: Routine doctor visits are essential to monitor the effectiveness of the treatment and minimize potential side effects.

Storage

• Temperature: Store Indomethacin 75mg SR Tablets at room temperature, between 20–25°C (68–77°F).
• Moisture and Light: Keep the medication in a dry place, away from direct sunlight and excessive moisture. Avoid storing it in bathrooms.
• Safety: Keep the tablets out of reach of children and pets to prevent accidental ingestion.
• Disposal: Dispose of unused or expired tablets responsibly, following local waste disposal guidelines.