Glyburide/Glibenclamide 2.5mg

Uses of Glyburide (Glibenclamide) 2.5mg

Glyburide 2.5mg is prescribed to:

• Control Blood Sugar Levels: Helps lower blood sugar in individuals with type 2 diabetes.
• Prevent Diabetes Complications: Reduces the risk of long-term complications, such as neuropathy, retinopathy, cardiovascular disease, and kidney damage.

This medication is not suitable for managing type 1 diabetes or diabetic ketoacidosis.

How Does Glyburide (Glibenclamide) 2.5mg Work?

Glyburide works by:

• Stimulating the pancreas to produce more insulin, which lowers blood sugar levels.
• Enhancing the body’s sensitivity to insulin, improving glucose utilization by the cells.

This dual action makes Glyburide effective in managing type 2 diabetes and maintaining steady blood sugar levels.

How to Use Glyburide (Glibenclamide) 2.5mg

• Dosage: The recommended starting dose is 2.5mg once daily, typically taken with breakfast or the first major meal of the day. Your doctor may adjust the dose based on your blood sugar levels and response to treatment.
• Administration: Swallow the tablet whole with water. Do not crush or chew the tablet.
• Timing: Take the medication at the same time every day for consistent blood sugar control.
• Missed Dose: If you forget a dose, take it as soon as you remember, unless it is close to your next scheduled dose. Avoid doubling up to make up for a missed dose.

Always follow your healthcare provider’s instructions for optimal results.

Side Effects

Common side effects of Glyburide 2.5mg include:

• Nausea or upset stomach
• Dizziness or headache
• Weight gain
• Increased sensitivity to sunlight

Rare but serious side effects include:

• Hypoglycemia (low blood sugar), with symptoms such as sweating, shakiness, confusion, or fainting
• Allergic reactions (rash, itching, or swelling)
• Liver dysfunction, with signs such as yellowing of the skin or eyes (jaundice)

If severe or unusual side effects occur, seek medical attention immediately.

Drug Interactions

Glyburide 2.5mg may interact with other medications, affecting its effectiveness or increasing the risk of side effects. Common interactions include:

• Insulin or Other Antidiabetic Drugs: May increase the risk of hypoglycemia.
• Beta-Blockers (e.g., Atenolol): Can mask the symptoms of low blood sugar, such as rapid heartbeat.
• NSAIDs (e.g., Ibuprofen): May enhance the blood sugar-lowering effect, increasing the risk of hypoglycemia.
• Diuretics (e.g., Furosemide): Can reduce Glyburide’s effectiveness.
• Corticosteroids: May elevate blood sugar levels, counteracting Glyburide’s effect.

Always inform your doctor about all medications, supplements, and herbal products you are taking.

Food Interactions

Glyburide can be taken with or without food, but consider the following:

• Alcohol: Can increase the risk of low blood sugar (hypoglycemia) and should be consumed in moderation.
• High-Sugar Foods: May counteract the medication’s effectiveness.

Discuss any dietary concerns with your healthcare provider to ensure optimal blood sugar control.

Contraindications

Glyburide 2.5mg is contraindicated in the following situations:

• Known allergy or hypersensitivity to Glyburide, sulfonylureas, or any of the medication’s components.
• Type 1 diabetes or diabetic ketoacidosis.
• Severe kidney or liver dysfunction.
• Pregnancy or breastfeeding, unless specifically prescribed by a doctor.

Your doctor will review your medical history to determine if Glyburide is safe for you.

Precautions and Warnings

• Risk of Hypoglycemia: Be cautious of low blood sugar, especially when skipping meals, overexerting, or consuming alcohol. Carry fast-acting sugar, such as glucose tablets, for emergencies.
• Regular Monitoring: Frequent blood sugar checks are recommended to assess the medication’s effectiveness.
• Sun Sensitivity: Use sunscreen and protective clothing to avoid sunburn, as Glyburide may increase sensitivity to sunlight.
• Driving and Machinery: Avoid activities requiring alertness if experiencing symptoms of low blood sugar or dizziness.
• Pregnancy and Breastfeeding: Discuss potential risks and benefits with your healthcare provider, as Glyburide is not typically recommended during pregnancy or breastfeeding.

Safety Information

• Emergency Situations: Seek immediate medical attention if you experience severe hypoglycemia or an allergic reaction.
• Overdose: Symptoms of overdose may include severe dizziness, confusion, or loss of consciousness due to low blood sugar. Contact a healthcare provider immediately if an overdose occurs.
• Regular Follow-Ups: Routine doctor visits are essential to monitor blood sugar levels and adjust the dosage if necessary.
• Storage Precautions: Keep the medication out of reach of children and pets to prevent accidental ingestion.

Storage

• Temperature: Store Glyburide 2.5mg tablets at room temperature, between 20–25°C (68–77°F).
• Moisture and Light: Keep the medication in a dry place, away from direct sunlight and excessive moisture. Avoid storing it in bathrooms.
• Safety: Ensure the medication is securely stored to prevent misuse.
• Disposal: Dispose of unused or expired tablets responsibly, following local waste disposal guidelines.