Fenofibrate 145mg

Fenofibrate 145mg Uses

Fenofibrate 145mg is a prescription medication primarily used to treat high cholesterol and triglyceride levels in the blood. It belongs to a class of drugs called fibrates, which work by reducing the production of triglycerides in the liver and promoting their breakdown in the bloodstream. By lowering these lipid levels, Fenofibrate helps reduce the risk of developing cardiovascular diseases, such as heart attack and stroke.

This medication is commonly prescribed for individuals with hypertriglyceridemia, mixed dyslipidemia, and other lipid disorders. It is often used alongside lifestyle modifications, such as a healthy diet, regular exercise, and weight management, to achieve optimal cholesterol control. Fenofibrate 145mg is especially effective in targeting very high triglyceride levels that can lead to pancreatitis if left untreated.

Fenofibrate may also benefit individuals with metabolic syndrome or diabetes by improving lipid profiles. However, it is not a substitute for statins and is typically used as an adjunct therapy in patients who cannot tolerate or require additional lipid-lowering effects beyond statins.

Drug Interactions

Fenofibrate 145mg can interact with several medications, potentially altering their effectiveness or increasing the risk of side effects. It is important to inform your doctor about all medications, supplements, and over-the-counter products you are taking to avoid potential interactions.

• Statins: When combined with statins like atorvastatin or simvastatin, the risk of muscle-related side effects, such as myopathy or rhabdomyolysis, may increase. Close monitoring is recommended when these drugs are used together.
• Blood Thinners (e.g., Warfarin): Fenofibrate can enhance the effects of anticoagulants, increasing the risk of bleeding. Regular monitoring of clotting parameters (INR) is essential for patients on both medications.
• Immunosuppressants (e.g., Cyclosporine): Combining Fenofibrate with cyclosporine may increase the risk of kidney damage. Dose adjustments and frequent kidney function tests may be required.
• Cholestyramine or Colestipol: These bile acid-binding resins can reduce the absorption of Fenofibrate. To avoid this, take Fenofibrate at least one hour before or four to six hours after these medications.

Always consult your healthcare provider before starting or stopping any medications to minimize the risk of drug interactions.

Food Interactions

Fenofibrate 145mg should be taken with food to enhance its absorption and maximize its effectiveness. While there are no significant food restrictions with this medication, certain dietary adjustments can complement its lipid-lowering effects.

• High-Fat Foods: While Fenofibrate targets high lipid levels, consuming a low-fat diet is crucial for improving treatment outcomes. Avoid foods rich in saturated and trans fats, such as fried items, processed snacks, and fatty meats.
• Alcohol: Excessive alcohol consumption can increase triglyceride levels and strain the liver. Limiting alcohol intake while on Fenofibrate is recommended.
• Omega-3 Fatty Acids: Incorporating foods rich in omega-3 fatty acids, such as fatty fish (e.g., salmon, mackerel) and flaxseeds, can help improve lipid profiles and reduce triglyceride levels.

A balanced diet, including whole grains, fruits, vegetables, and lean protein, supports the medication’s effectiveness in managing cholesterol and triglycerides.

Contraindications

Fenofibrate 145mg is not suitable for everyone, and specific medical conditions or factors may make its use unsafe.

• Severe Liver or Kidney Disease: Fenofibrate is metabolized by the liver and excreted through the kidneys. Patients with severe liver or kidney impairment should not use this medication.
• Gallbladder Disease: Fenofibrate may increase the risk of gallstones, making it unsuitable for individuals with a history of gallbladder disease.
• Allergy to Fenofibrate: Individuals who are allergic to Fenofibrate or its components should avoid using this medication.
• Pregnancy and Breastfeeding: Fenofibrate is not recommended during pregnancy or breastfeeding due to the potential risk of harm to the fetus or infant.

Before starting Fenofibrate 145mg, discuss your full medical history with your doctor to determine if it is a suitable treatment option for you.

Precautions and Warnings

While Fenofibrate 145mg is effective in managing lipid levels, certain precautions must be taken to ensure safe and effective use.

• Liver Function Monitoring: Fenofibrate can affect liver enzymes, so regular liver function tests are recommended. If abnormal results are detected, discontinuation of the medication may be necessary.
• Kidney Function: Patients with mild to moderate kidney impairment may require dosage adjustments and frequent monitoring to avoid complications.
• Muscle Side Effects: Fenofibrate may cause muscle-related side effects, such as muscle pain, weakness, or tenderness, particularly when used with statins. Report any unusual muscle symptoms to your doctor immediately.
• Risk of Pancreatitis: Although rare, Fenofibrate can cause pancreatitis in certain individuals. Symptoms like severe abdominal pain, nausea, or vomiting should be reported promptly.
• Use in Older Adults: Older adults may be more sensitive to the effects of Fenofibrate and should be monitored closely during treatment.

Always follow your doctor’s instructions regarding dosage and duration of treatment to minimize risks and maximize benefits.

Storage

Proper storage of Fenofibrate 145mg ensures the medication remains effective and safe for use.

• Temperature: Store Fenofibrate at room temperature, typically between 20°C and 25°C (68°F and 77°F). Avoid exposing the medication to extreme temperatures.
• Moisture and Light: Keep the tablets in their original packaging, away from moisture, heat, and direct sunlight. Do not store them in humid areas, such as bathrooms.
• Child Safety: Store the medication out of reach of children and pets to prevent accidental ingestion.
• Disposal: Dispose of unused or expired Fenofibrate responsibly, following local regulations or returning it to a pharmacy for proper disposal.