Dasatinib 50mg Uses

Dasatinib 50mg is prescribed to:

  • Treat newly diagnosed adults with chronic myeloid leukemia (CML) in the chronic phase.
  • Manage chronic, accelerated, or blast phase CML that is resistant to or intolerant of previous treatments, such as imatinib.
  • Treat adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

How Does Dasatinib 50mg Work

Dasatinib works by inhibiting specific tyrosine kinases, such as the BCR-ABL protein, which are essential for cancer cell growth and survival in CML and Ph+ ALL. By blocking these kinases, Dasatinib disrupts the growth of abnormal cells, reducing the disease’s impact on the body.

How to Use Dasatinib 50mg

  • Take Dasatinib 50mg exactly as prescribed by your healthcare provider.
  • Swallow the tablet whole with a full glass of water; do not crush, chew, or break the tablet.
  • It can be taken with or without food, but take it at the same time each day to maintain consistent blood levels.
  • Avoid grapefruit and grapefruit juice, as they may interfere with the metabolism of Dasatinib.

Important Notes

  • Regular blood tests are required to monitor blood cell counts and organ function during treatment.
  • Do not alter or discontinue the dosage without consulting your healthcare provider.

Side Effects

Common side effects may include:

  • Fatigue or weakness
  • Diarrhea or nausea
  • Skin rash
  • Muscle or joint pain

Rare but serious side effects include:

  • Low blood cell counts (anemia, neutropenia, or thrombocytopenia), increasing the risk of infection or bleeding
  • Fluid retention, which may cause swelling, shortness of breath, or chest pain
  • Severe gastrointestinal bleeding or other significant bleeding episodes
  • Liver or kidney function abnormalities

Drug Interactions

Dasatinib 50mg may interact with:

  • Proton pump inhibitors (PPIs) or antacids, which may reduce its absorption.
  • Blood thinners or anticoagulants, which may increase the risk of bleeding.
  • Medications that affect liver enzymes, such as certain antifungals, antibiotics, or antivirals, which may alter its effectiveness.

Inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.

Food Interactions

  • Avoid grapefruit and grapefruit juice, as they may increase Dasatinib levels in the blood and raise the risk of side effects.
  • Maintain a balanced diet to support your overall health during cancer treatment.

Dasatinib 50mg Contraindications

This medication is not suitable for:

  • Individuals allergic to Dasatinib or its components.
  • Patients with severe liver impairment without medical supervision.
  • Pregnant or breastfeeding women, as it may harm the fetus or infant.

Precautions and Warnings

  • Inform your healthcare provider if you have a history of liver or kidney disease, heart conditions, or bleeding disorders.
  • Use with caution if you have low blood cell counts or a weakened immune system.
  • Regular monitoring of blood counts and organ function is essential during treatment.
  • Women of childbearing age should use effective contraception to avoid pregnancy during treatment.

Storage

  • Store Dasatinib 50mg tablets at room temperature, away from moisture, heat, and direct sunlight.
  • Keep the tablets in their original packaging and out of reach of children and pets.
  • Dispose of unused or expired tablets responsibly, following local disposal regulations.

Safety Information

  • Take this medication only as directed by your healthcare provider.
  • Do not exceed the prescribed dose or stop taking it without medical advice.
  • Report any unusual symptoms, such as severe fatigue, swelling, or unexplained bleeding, to your doctor immediately.
Quantity 120, 180, 240, 60
Manufacturer Natco
Indian Brand Dasanat 50mg
US Brand Name Dasatinib, Sprycel
Generic Name Dasatinib
Dosage 50mg
Drug Type Tablets
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