Chlorambucil 5mg Uses

Chlorambucil is effective in managing:

  • Chronic lymphocytic leukemia (CLL)
  • Hodgkin’s lymphoma
  • Non-Hodgkin’s lymphoma
  • Waldenström’s macroglobulinemia
  • Ovarian cancer (as a secondary treatment)

It is also used in some cases for autoimmune disorders when other treatments have failed, due to its immune-suppressing effects.

How Does Chlorambucil 5mg Work

Chlorambucil functions by causing cross-linking of DNA strands, ultimately leading to a reduction in DNA synthesis and function. This disruption is particularly effective against rapidly dividing cells, such as cancer cells, slowing disease progression and helping to manage symptoms.

How to Use Chlorambucil 5mg

Chlorambucil should be taken according to the specific instructions provided by a healthcare provider, typically on an empty stomach, usually once daily. The dosage and duration of treatment depend on the type of cancer, the patient’s weight, medical condition, and response to therapy. It’s crucial not to adjust the dosage without consulting a doctor. Adequate hydration is recommended during treatment to help avoid kidney damage.

Side Effects

Common side effects of Chlorambucil include:

  • Bone marrow suppression
  • Nausea and vomiting
  • Diarrhea
  • Mouth ulcers
  • Increased risk of infection
  • Anemia
  • Unusual bleeding or bruising

More severe side effects require immediate medical attention, including signs of liver problems, severe neurological issues, or intense gastrointestinal distress.

Drug Interactions

Chlorambucil can interact with other chemotherapy treatments, vaccines, and medications that suppress the immune system, increasing the risk of infections or other severe complications. Patients should always inform their healthcare provider about all medications they are taking, including over-the-counter drugs and supplements.

Food Interactions

No specific food interactions with Chlorambucil require dietary restrictions, but patients are generally advised to discuss their diet with a healthcare provider to ensure optimal nutritional intake during cancer treatment.

Contraindications

Chlorambucil is contraindicated in patients with a known allergy to the medication or any of its components. It should not be used in pregnant or breastfeeding women due to the potential for severe harm to the fetus or baby.

Precautions and Warnings

  • Pregnancy and Breastfeeding: Avoid use due to potential risk to the fetus or nursing infant.
  • Infection Risk: Patients are more susceptible to infections; monitoring and preventive care may be necessary.
  • Blood Counts: Frequent monitoring of blood cell counts is essential, as Chlorambucil can lead to severe bone marrow suppression.
  • Secondary Cancers: Long-term use of Chlorambucil can increase the risk of developing secondary cancers, particularly of the skin and other organs.

Storage

Store Chlorambucil 5mg in a cool, dry place, away from light and moisture. Keep all medications out of reach of children and pets to prevent accidental ingestion.

Handling Chlorambucil requires careful attention to safety guidelines to avoid exposure during handling and disposal, as it is a potent chemotherapy agent.

Quantity 120, 30, 60, 90
Manufacturer Natco Pharma Ltd
Indian Brand Clokeran 5mg Tablet
US Brand Name Chlorambucil 5mg
Generic Name Chlorambucil
Dosage 5mg
Drug Type Tablets
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