Clarithromycin Side Effects
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Written By: Kevin P
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March 27, 2026
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Written By Kevin P
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Medically Reviewed by Dr. Jacqueline P – General Practitioner
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Last Updated On March 27, 2026
Common Side Effects: The "Big Three"
Most of the people who might take clarithromycin to tolerate it well. However, as it is an antibiotic, this medicine is commonly known to affect the digestive system. Some of the most frequent conditions are mentioned below:- Stomach Upset: One shall simply feel nauseated or even vomit. While using the dosage with that smaller meal or a glass of milk can usually help in settling the stomach right.
- Diarrhea: Antibiotics like medicines can simply disrupt the natural balance of bacteria in the gut. While condition of diarrhea is mild, you need to focus on staying hydrated on using water or broth.
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- A "Metallic" Taste: A unique side effect of the medicine clarithromycin is a temporary change in taste. There are many people who shall describe it as a bitter or metallic flavor in the mouth. This can further be about going away once you finish the medication.
Rare but Serious Side Effects
While rare, some of the side effects might need immediate medical attention. While some might also experience any of the following, contact the healthcare provider right away.- Liver Problems
- Heart Rhythm Changes
- Severe Allergic Reactions
- Swelling of the face, lips, or tongue.
- Difficulty breathing or wheezing.
- A severe skin rash that looks like blisters or peeling skin.
Special Warnings
As the medicine clarithromycin is a powerful solution, there are specific situations where extra caution is needed.- Drug Interactions: Medicine Clarithromycin is famous for not "playing well" with other medicines. This can further be dangerously increases the levels of some specific medicines in the blood. This is also about some statins (for cholesterol), blood thinners (like warfarin), and some of the heart medications. Always give the pharmacist a full list of everything you take, like those herbal supplements.
- Pregnancy and Breastfeeding: This solution is usually not recommended during pregnancy. This goes especially well in the first three months, as it might be harming the developing baby.
- The "Second Infection": While one shall develop severe, watery diarrhoea with stomach cramps even weeks after finishing course of the medicine, do not treat it with over-the-counter anti-diarrhoea medicine.
How to Manage Side Effects at Home
If you are dealing with some of the mild side effects, they can be simply using some simple step that can make your recovery easier:- Stick to Bland Foods: While feeling sick, avoid spicy or fatty meals. Think of the "BRAT" diet, which includes: Bananas, Rice, Applesauce, and Toast.
- Stay Hydrated: Getting affected with diarrhea and vomiting can eventually lead to dehydration quickly. Drink plenty of fluids throughout the day can help.
- Timing is Key: Unless the doctor says otherwise, try to take those dosages of the medicine at the same time every day to keep a steady level of medicine in the body. If you use the extended-release version (often it is known as labeled XL), you must take it with food.
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