Tenofovir Disoproxil Fumarate 300mg Uses

Tenofovir Disoproxil Fumarate 300mg is prescribed to:

  • Treat HIV-1 infection in adults and adolescents as part of a combination antiretroviral therapy (ART).
  • Manage chronic hepatitis B infection to reduce viral replication and liver inflammation.
  • Decrease the risk of disease progression, including the development of cirrhosis and liver cancer in HBV patients.

How Does Tenofovir Disoproxil Fumarate 300mg Work

Tenofovir Disoproxil Fumarate inhibits the action of reverse transcriptase, an enzyme necessary for the replication of HIV and HBV. By incorporating itself into the viral DNA, it prevents the virus from multiplying, reducing the viral load and improving immune system function.

How to Use Tenofovir Disoproxil Fumarate 300mg

  • Take Tenofovir 300mg exactly as prescribed by your healthcare provider, usually once daily.
  • Swallow the tablet whole with water, with or without food.
  • Take the medication at the same time each day to maintain consistent blood levels.
  • Adherence to the prescribed schedule is crucial for preventing drug resistance and ensuring effectiveness.

Side Effects

Common side effects may include:

  • Nausea, vomiting, or diarrhea
  • Dizziness or headache
  • Fatigue or weakness
  • Flatulence

Rare but serious side effects include:

  • Lactic acidosis, with symptoms such as unusual muscle pain, trouble breathing, or extreme fatigue
  • Severe liver damage, with symptoms like yellowing of the skin or eyes, dark urine, or abdominal pain
  • Kidney problems, with symptoms such as swelling in the feet or reduced urination
  • Bone thinning or fractures

Drug Interactions

Tenofovir Disoproxil Fumarate 300mg may interact with:

  • Other antiretroviral medications, which may require dosage adjustments.
  • NSAIDs, which may increase the risk of kidney problems.
  • Medications that affect the kidneys, such as aminoglycosides or high-dose antivirals.

Food Interactions

  • Tenofovir can be taken with or without food. However, taking it with a meal may help reduce stomach upset.
  • Avoid excessive alcohol consumption, as it may increase the risk of liver toxicity.

Tenofovir Disoproxil Fumarate 300mg Contraindications

This medication is not suitable for:

  • Individuals allergic to Tenofovir or any of its components.
  • Patients with severe renal impairment unless advised and closely monitored by a healthcare provider.
  • Patients co-infected with HBV and not on HBV treatment, as abrupt discontinuation may exacerbate HBV.

Precautions and Warnings

  • Inform your doctor if you have a history of kidney disease, liver disease, or bone problems.
  • Regular blood tests are necessary to monitor kidney function, liver health, and viral loads.
  • Women who are pregnant or breastfeeding should consult their doctor before using this medication.
  • Do not discontinue the medication without medical advice, as this may lead to viral rebound or worsening symptoms.

Storage

  • Store Tenofovir 300mg tablets at room temperature, away from heat, moisture, and direct sunlight.
  • Keep the tablets in their original packaging and out of reach of children and pets.
  • Dispose of unused or expired tablets responsibly, following local disposal regulations.

Safety Information

  • Use Tenofovir Disoproxil Fumarate 300mg only as directed by your healthcare provider.
  • Adherence to treatment is critical to prevent drug resistance and ensure effectiveness.
  • Report any unusual symptoms, such as muscle weakness, breathing difficulties, or severe fatigue, to your healthcare provider immediately.
Quantity 120, 30, 60, 90
Manufacturer Cipla Limited
Indian Brand Tenvir
US Brand Name Tenofovir Disoproxil Fumarate, Viread
Generic Name Tenofovir Disoproxil Fumarate
Dosage 300mg
Drug Type Tablets
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