Lamivudine-Zidovudine-Nevirapine 150mg-300mg-200mg

Uses of Lamivudine-Zidovudine-Nevirapine 150mg-300mg-200mg

Lamivudine-Zidovudine-Nevirapine is used to:

• Manage HIV infection by reducing viral load and improving immune system function.
• Delay the progression of HIV to Acquired Immunodeficiency Syndrome (AIDS).
• Prevent mother-to-child transmission of HIV as part of a comprehensive treatment plan.

This medication is not a cure for HIV but helps manage the infection effectively when used consistently as prescribed.

How Does Lamivudine-Zidovudine-Nevirapine Work?

This combination medication works by targeting different stages of the HIV replication cycle:

• Lamivudine (150mg): Inhibits the reverse transcriptase enzyme, blocking the conversion of viral RNA into DNA.
• Zidovudine (300mg): Works similarly by preventing the integration of viral DNA into the host cell genome.
• Nevirapine (200mg): A non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds directly to reverse transcriptase, halting the replication process.

The combined action of these drugs reduces the viral load and helps maintain a functioning immune system.

How to Use Lamivudine-Zidovudine-Nevirapine 150mg-300mg-200mg

• Dosage: Typically, one tablet is taken twice daily or as directed by your healthcare provider.
• Administration: Swallow the tablet whole with a glass of water. It can be taken with or without food.
• Timing: Maintain consistent dosing intervals to ensure steady drug levels in the blood.
• Missed Dose: Take the missed dose as soon as you remember, unless it is close to your next scheduled dose. Do not double the dose to make up for a missed one.

Follow your healthcare provider’s instructions carefully for safe and effective use.

Side Effects

Common side effects of Lamivudine-Zidovudine-Nevirapine include:

• Nausea or vomiting
• Fatigue or headache
• Diarrhea or abdominal pain
• Rash (common with Nevirapine, especially during the first few weeks)

Rare but serious side effects include:

• Lactic acidosis, with symptoms such as muscle pain, trouble breathing, or unusual fatigue
• Severe anemia or neutropenia
• Liver toxicity, indicated by yellowing of the skin or eyes (jaundice)
• Severe allergic reactions such as rash, swelling, or difficulty breathing

Seek immediate medical attention if you experience severe or persistent side effects.

Drug Interactions

Lamivudine-Zidovudine-Nevirapine may interact with other medications, leading to increased side effects or reduced effectiveness. Common interactions include:

• Rifampin: Can reduce the effectiveness of Nevirapine.
• Methadone: May require dosage adjustments as Zidovudine levels can be affected.
• Bone Marrow Suppressants: May increase the risk of low blood cell counts.
• Drugs Affecting Liver Enzymes: Can alter Nevirapine levels, increasing toxicity risks.

Inform your doctor about all medications, supplements, and herbal products you are using before starting treatment.

Food Interactions

Lamivudine-Zidovudine-Nevirapine can be taken with or without food. Avoid alcohol as it may increase the risk of liver toxicity and other side effects. Discuss specific dietary recommendations with your healthcare provider.

Contraindications

Lamivudine-Zidovudine-Nevirapine is contraindicated in individuals with:

• Known hypersensitivity to Lamivudine, Zidovudine, Nevirapine, or any other ingredients in the formulation.
• Severe liver dysfunction or history of liver-related complications.
• Severe anemia or neutropenia.

Your healthcare provider will evaluate your medical history to ensure this medication is appropriate for you.

Precautions and Warnings

• Liver Monitoring: Regular liver function tests are essential, especially during the first 18 weeks of treatment, as Nevirapine carries a risk of liver toxicity.
• Lactic Acidosis: Watch for symptoms such as muscle pain, fatigue, or breathing difficulties.
• Bone Marrow Suppression: Regular blood tests are needed to monitor red and white blood cell levels.
• Pregnancy and Breastfeeding: Consult your doctor before using this medication if you are pregnant or breastfeeding.
• HIV Transmission: This medication does not prevent the transmission of HIV to others. Use protective measures such as condoms to reduce the risk.

Safety Information

Seek immediate medical attention if you experience severe allergic reactions, symptoms of liver toxicity, or unusual bleeding. Overdose symptoms may include extreme fatigue, nausea, or jaundice. Contact a healthcare provider or poison control center immediately if overdose occurs. Routine follow-ups with your doctor are necessary to monitor effectiveness and side effects.

Storage

• Temperature: Store Lamivudine-Zidovudine-Nevirapine 150mg-300mg-200mg tablets at room temperature, between 20–25°C (68–77°F).
• Moisture and Light: Keep the medication in a dry place, away from direct sunlight and excessive moisture. Avoid storing it in bathrooms.
• Safety: Keep out of reach of children and pets.
• Disposal: Dispose of unused or expired tablets responsibly, following local waste disposal guidelines.