Lamivudine-Zidovudine 150mg-300mg

Uses of Lamivudine-Zidovudine 150mg-300mg

Lamivudine-Zidovudine 150mg-300mg is used to:

• Manage HIV infection by reducing the viral load in the blood.
• Improve immune function and delay the progression of HIV to Acquired Immunodeficiency Syndrome (AIDS).
• Prevent mother-to-child transmission of HIV when used as part of a comprehensive treatment plan.

This medication is not a cure for HIV but helps manage the infection effectively.

How Does Lamivudine-Zidovudine 150mg-300mg Work?

Lamivudine-Zidovudine works by:

• Lamivudine: Inhibits the reverse transcriptase enzyme, preventing the virus from converting its RNA into DNA, which is essential for viral replication.
• Zidovudine: Works similarly by blocking the replication process, reducing the amount of virus in the body.

The combination enhances the antiviral effect, making it more effective in managing HIV infection.

How to Use Lamivudine-Zidovudine 150mg-300mg

• Dosage: The typical dose is one tablet taken twice daily, or as directed by your healthcare provider.
• Administration: Swallow the tablet whole with a glass of water. It can be taken with or without food.
• Timing: Maintain consistent dosing intervals to ensure steady drug levels in the body.
• Missed Dose: Take the missed dose as soon as you remember. If it is close to your next scheduled dose, skip the missed dose. Do not double the dose to make up for a missed one.

Follow your healthcare provider’s instructions for safe and effective use.

Side Effects

Common side effects of Lamivudine-Zidovudine 150mg-300mg include:

• Nausea or vomiting
• Diarrhea or abdominal pain
• Fatigue or headache
• Dizziness

Rare but serious side effects include:

• Lactic acidosis, which may cause symptoms such as muscle pain, trouble breathing, or unusual fatigue
• Severe anemia or low white blood cell count
• Liver problems, indicated by yellowing of the skin or eyes (jaundice)
• Allergic reactions such as rash, swelling, or difficulty breathing

Seek immediate medical attention if you experience severe or persistent side effects.

Drug Interactions

Lamivudine-Zidovudine 150mg-300mg may interact with other medications, leading to increased side effects or reduced effectiveness. Common interactions include:

• Antiviral Drugs (e.g., Ribavirin): May increase the risk of side effects like anemia.
• Bone Marrow Suppressants: May exacerbate the risk of low blood cell counts.
• Methadone: May affect the blood levels of Zidovudine.
• Drugs Affecting the Kidneys: May increase the risk of toxicity.

Inform your healthcare provider about all medications, supplements, and herbal products you are using before starting treatment.

Food Interactions

Lamivudine-Zidovudine 150mg-300mg can be taken with or without food. Avoid alcohol as it may increase the risk of liver toxicity and side effects. Discuss any specific dietary recommendations with your healthcare provider.

Contraindications

Lamivudine-Zidovudine 150mg-300mg is contraindicated in individuals with:

• Known hypersensitivity to Lamivudine, Zidovudine, or any other ingredients in the formulation.
• Severe liver or kidney impairment.
• A history of severe anemia or low white blood cell count.

Your healthcare provider will evaluate your medical history to ensure this medication is safe for you.

Precautions and Warnings

• Lactic Acidosis Risk: Monitor for symptoms such as muscle pain, trouble breathing, or unusual fatigue.
• Bone Marrow Suppression: Regular blood tests may be needed to monitor red and white blood cell levels.
• Liver Monitoring: Regular liver function tests are recommended, especially in individuals with a history of liver disease.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant or breastfeeding, as the medication may pose risks to the baby.
• HIV Transmission: This medication does not prevent the transmission of HIV to others. Use protective measures such as condoms to reduce the risk.

Safety Information

Seek immediate medical attention if you experience severe allergic reactions, symptoms of lactic acidosis, or unusual bleeding. Overdose symptoms may include severe fatigue, nausea, or jaundice. Contact a healthcare provider or poison control center immediately if overdose occurs. Routine follow-ups with your doctor are essential to monitor effectiveness and side effects.

Storage

• Temperature: Store Lamivudine-Zidovudine 150mg-300mg tablets at room temperature, between 20–25°C (68–77°F).
• Moisture and Light: Keep the medication in a dry place, away from direct sunlight and excessive moisture. Avoid storing it in bathrooms.
• Safety: Keep out of reach of children and pets.
• Disposal: Dispose of unused or expired tablets responsibly, following local waste disposal guidelines.