Understanding the Condition:

Type 2 diabetes mellitus (T2DM) is known to be a chronic metabolic disorder. The issue is that the body might be resistant to insulin, or it can fail to produce enough amount of insulin to regulate blood sugar effectively. Insulin is essential for transporting glucose from the bloodstream into the cells, where it is used for energy.  

In T2DM, excess glucose accumulates in the blood, which leads to hyperglycemia.   

Untreated or poorly controlled diabetes can result in severe complications, which include:   

Heart disease and stroke condition 

Kidney failure (leading to diabetic nephropathy)   

Vision loss (like diabetic retinopathy)   

Nerve damage (neuropathy)   

Diabetic foot ulcers that might lead to amputation   

 Effective management of T2DM needs a combination of healthy eating, physical activity, and medications. It can help to regulate blood sugar. Glyburide/Glibenclamide-Metformin 2.5mg-400mg medicine offers a dual mechanism that shall enhance glycemic control in patients with T2DM. It can also lower the risk of long-term complications. 

What Does Glyburide/Glibenclamide-Metformin 2.5mg-400mg Treat? 

Glyburide/Glibenclamide-Metformin 2.5mg-400mg medication is indicated for the treatment of Type 2 diabetes mellitus (T2DM). The medication is suitable for individuals whose blood sugar levels are not controlled through diet, exercise, or monotherapy (which is a single drug). Glyburide-Metformin helps in managing:   

Fasting blood glucose levels (morning readings)   

Postprandial glucose levels (post meals)   

Long-term HbA1c (which is a measure of average blood glucose over three months),The goal of such treatment is to simply achieve glycemic control. This can lower the risk of diabetes-related complications, and it can also enhance the patient’s quality of life. 

How Does Glyburide/Glibenclamide-Metformin 2.5mg-400mg Work? 

The combination of this medication can offer two complementary actions for blood sugar control:   

  1. Glyburide/Glibenclamide (2.5mg):  

Glyburide medication is a sulfonylurea that promotes insulin release from the pancreas, even when blood sugar levels are only moderately elevated.   

The medicine works by stimulating beta cells in the pancreas, which will enhance insulin secretion.   

Glyburide is super effective in lowering postprandial glucose levels (post those after-meal spikes). 

  1. Metformin (400mg):  

Metformin is a biguanide that lowers the production of glucose in the liver (which is also known as hepatic gluconeogenesis).   

It enhances insulin sensitivity in muscle and fat tissues, which can further help the cells to absorb glucose efficiently.   

Metformin in Glyburide/Glibenclamide-Metformin 2.5mg-400mg also slows the absorption of glucose from the intestines. This complete action leads to better fasting glucose control.   

The dual approach makes Glyburide/Glibenclamide-Metformin medicine effective in treating patients who might need comprehensive glycemic management. This shall also target both insulin secretion and insulin resistance. 

How To Use Glyburide/Glibenclamide-Metformin 2.5mg-400mg?

Consume the Glyburide/Glibenclamide-Metformin 2.5mg-400mg medication with meals to lower gastrointestinal side effects and minimize the risk of hypoglycemia.   

You must never alter the state of medicine by crushing or chewing; swallow it as a whole with a glass of water.   

If prescribed once daily, take the medicine with breakfast. When you are to take it twice a day, the second dosage is to be consumed with the evening meal.   

Sustain a consistent schedule for consumption of the medicine which shall ensure steady blood glucose control.   

It is also essential to monitor blood sugar levels regularly and report any unusual changes to the healthcare provider.   

Dosage Instructions 

Starting Dose: The initial dosage of this medicine is usually low, which allows healthcare providers to monitor response and gradually enhance the dosage.   

Adjustments: Dose adjustments can all depend on the blood sugar levels and ability to tolerate the medication.   

Missed Dose: In case you have missed a dose, consume the missed one, as soon as you remember. However, if it’s time for your next scheduled dose, skip the missed dose.  

Possible Side Effects

Like any of the medication, Glyburide/Glibenclamide-Metformin 2.5mg-400mg might lead to some side effects. Such issues can range from mild to severe.   

Some common side effects of consuming dual-acting pills include:   

Diarrhea, nausea or vomiting  

Abdominal discomfort or certain bloating  

Dizziness or headache   

Mild hypoglycemia (low blood sugar)   

Other severe Side Effects are:   

Severe hypoglycemia: Symptoms like confusion, sweating, blurred vision, and shakiness.   

Lactic acidosis: Metformin, which is marked by muscle pain, trouble breathing, extreme fatigue, and stomach discomfort.   

Allergic reactions: itching, rashes, swelling, or issues in breathing.   

Liver or kidney dysfunction: It needs some routine monitoring by the doctor.   

Drug Interactions 

Some medications and substances can simply interact with Glyburide/Glibenclamide-Metformin 2.5mg-400mg, potentially altering its effectiveness.

Alcohol: It increases the risk of hypoglycemia and lactic acidosis.   

Beta-blockers: Might mask some symptoms of hypoglycemia, which shall make it harder to detect low blood sugar.   

Diuretics and corticosteroids: Can raise blood sugar levels.   

ACE inhibitors and NSAIDs: Enhances the risk of hypoglycemia when taken with Glyburide.   

Some other antidiabetic drugs: When combined with insulin or other oral antidiabetics, there is a higher chance of a hypoglycemia-like condition.   

It is essential to inform the healthcare provider about all the medications and supplements that are being consumed to avoid potential interactions.  

Precautions

Kidney and liver function: Regular monitoring is much needed, as Metformin and Glyburide can affect such organs.   

Heart conditions: You are to use this medicine cautiously in patients with a history of heart disease or heart failure.   

Pregnancy and breast-feeding: Such medication is usually not recommended safe for consumption during pregnancy or while breastfeeding. Consult the doctor about suitable alternatives.   

Elderly patients: Older adults are more susceptible to hypoglycemia.   

Surgical procedures: When you are undergoing surgery or quick diagnostic tests, the doctor might temporarily stop this pill. 

How To Store Glyburide/Glibenclamide-Metformin 2.5mg-400mg? 

Keep the medication in a cool, dry place, right away from the direct reach of sunlight and moisture.   

Keep Glyburide/Glibenclamide-Metformin 2.5mg-400mg pills at room temperature (15-30°C).   

Ensure that the solution is kept out of the reach of children and pets.   

You must never use expired medication. And make sure you dispose of it properly by consulting the pharmacist. 

Fact Box

  • Drug Category: Oral Antidiabetic Combination   
  • Manufacturer: Sun Pharma 
  • Therapeutic Category: Diabetes Management   
  • Available Dosage Types: Oral Tablets   
  • Ailment: Type 2 Diabetes Mellitus   
  • Other Brand Names: Glucovance and Glyburide-Metformin 
  • Dosage: Glyburide/Glibenclamide 2.5mg and Metformin 400mg 

Conclusion

Glyburide/Glibenclamide-Metformin 2.5mg-400mg pill is an effective medicine that manages Type 2 diabetes mellitus. This goes well, especially for patients who struggle with insulin resistance and might need additional support to control postprandial blood sugar levels.

Quantity 120, 30, 60, 90
Manufacturer Sun Pharma
Indian Brand Glucored
US Brand Name Glucovance, Glyburide-Metformin
Generic Name Glyburide/Glibenclamide-Metformin
Dosage 2.5mg-400mg
Drug Type Tablets
Be the first to review “Glyburide/Glibenclamide-Metformin 2.5mg-400mg”

Your email address will not be published. Required fields are marked *


Reviews

There are no reviews yet.

Product was successfully added to your cart!