Fluconazole 150mg Uses

Fluconazole 150mg is a widely used antifungal medication designed to treat and prevent a variety of fungal and yeast infections. It belongs to the azole antifungal class, which works by inhibiting the growth of fungi by disrupting their cell membrane integrity. This makes it an effective option for treating infections and preventing their recurrence.

Fluconazole 150mg is commonly prescribed for:

  • Vaginal Candidiasis (Yeast Infection): A single-dose treatment for vaginal yeast infections, relieving symptoms such as itching, irritation, and abnormal discharge.
  • Oropharyngeal Candidiasis (Thrush): A fungal infection in the mouth and throat.
  • Systemic Candidiasis: Treats serious fungal infections affecting internal organs or multiple systems in the body.
  • Cryptococcal Meningitis: Used in the treatment and prevention of this severe fungal infection in patients with weakened immune systems, such as those with HIV/AIDS.
  • Prophylaxis: Prevents fungal infections in immunocompromised individuals, including those undergoing chemotherapy or organ transplants.

Fluconazole 150mg is also used off-label for certain fungal infections as determined by a healthcare provider. Its single-dose regimen for some conditions, like vaginal candidiasis, makes it a convenient choice for patients.

Drug Interactions

Fluconazole 150mg may interact with other medications, potentially altering its effectiveness or increasing the risk of side effects. Always inform your doctor about all medications, supplements, and herbal products you are using to avoid potential drug interactions.

  • Warfarin: Fluconazole can enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Regular monitoring of INR levels is recommended.
  • Oral Hypoglycemics (e.g., Glipizide, Glyburide): The medication may enhance the effects of these drugs, leading to hypoglycemia. Blood sugar levels should be closely monitored.
  • Statins (e.g., Atorvastatin, Simvastatin): Combining Fluconazole with statins can increase the risk of muscle-related side effects like rhabdomyolysis.
  • Benzodiazepines (e.g., Midazolam, Diazepam): Fluconazole may amplify the sedative effects of these drugs.
  • Rifampin: This antibiotic can reduce the effectiveness of Fluconazole, necessitating dosage adjustments.
  • Cisapride, Pimozide, and Terfenadine: These medications are contraindicated with Fluconazole due to the risk of serious cardiac arrhythmias.

Food Interactions

Fluconazole 150mg can be taken with or without food, offering flexibility in administration. While it has no significant food-related restrictions, certain dietary considerations may improve its effectiveness and minimize potential side effects.

  • Alcohol: Although Fluconazole does not directly interact with alcohol, limiting alcohol intake is advisable. Alcohol can weaken the immune system and may exacerbate liver-related side effects of the medication.
  • Hydration: Drink plenty of water to support kidney function and promote recovery from systemic infections.
  • Immune-Supporting Diet: Incorporate foods rich in vitamins, minerals, and antioxidants, such as fresh fruits, vegetables, and whole grains, to strengthen the immune system and enhance overall recovery.

Maintaining a balanced diet and staying hydrated can help maximize the benefits of Fluconazole 150mg while promoting overall health.

Contraindications

Fluconazole 150mg is not suitable for everyone. Certain medical conditions or circumstances may make its use unsafe.

  • Allergy to Fluconazole or Azole Antifungals: Patients with a known hypersensitivity to Fluconazole or other azole antifungal agents (e.g., Itraconazole, Ketoconazole) should avoid this medication.
  • Concurrent Use of Specific Medications: Drugs such as cisapride, pimozide, and terfenadine are contraindicated due to the risk of life-threatening cardiac arrhythmias.
  • Pregnancy: Fluconazole is generally not recommended during pregnancy, especially in high doses, as it may pose a risk to the developing fetus. Pregnant women should discuss alternative treatments with their doctor.
  • Severe Liver Disease: Individuals with significant liver impairment may not be suitable candidates for Fluconazole treatment due to the potential for hepatotoxicity.

Always inform your doctor about your medical history and current health status to ensure that Fluconazole 150mg is a safe option for your condition.

Precautions and Warnings

To ensure the safe and effective use of Fluconazole 150mg, observe the following precautions:

  • Liver Function Monitoring: Fluconazole can elevate liver enzymes, which may indicate liver damage in rare cases. Regular liver function tests are recommended, especially for long-term use.
  • Kidney Function: As Fluconazole is eliminated through the kidneys, patients with impaired kidney function may require dosage adjustments. Routine kidney function monitoring is advised in such cases.
  • QT Prolongation: Fluconazole can cause QT interval prolongation, a heart rhythm condition. Patients with a history of cardiac issues or those on medications that affect the QT interval should use this drug with caution.
  • Pregnancy and Breastfeeding: Women who are pregnant or breastfeeding should consult their doctor before using Fluconazole. Alternative treatments may be recommended depending on the infection and its severity.
  • Drug Resistance: To avoid fungal resistance, complete the full course of Fluconazole as prescribed, even if symptoms improve before finishing the medication.

Follow your healthcare provider’s guidance closely to minimize risks and ensure effective treatment.

Storage

Proper storage of Fluconazole 150mg ensures its potency and safety throughout its shelf life.

  • Temperature: Store Fluconazole at room temperature, typically between 20°C and 25°C (68°F and 77°F). Avoid exposing it to excessive heat or cold.
  • Moisture and Light: Keep the medication in its original packaging, away from moisture and direct sunlight. Avoid storing it in humid areas such as bathrooms.
  • Child Safety: Store Fluconazole out of reach of children and pets to prevent accidental ingestion.
  • Expiration Date: Always check the expiration date before use. Do not use expired medication, as it may lose its effectiveness or pose health risks.
  • Disposal: Dispose of unused or expired Fluconazole responsibly, following local guidelines or returning it to a pharmacy for proper disposal.
Quantity 10, 20, 30, 40
Manufacturer Torrent Pharmaceuticals Ltd
Indian Brand Syscan 150mg
US Brand Name Canesoral, Diflucan, Dizole, Fluconazole, Fluzole, Ozole
Generic Name Fluconazole
Dosage 150mg
Drug Type Capsules
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